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Establishing Functional Biomarkers for Spaced Theta-Burst Stimulation
Not Recruiting
Trial ID: NCT03687892
Purpose
The investigators plan to use functional magnetic resonance imaging (fMRI) methods to assess
brain changes following spaced theta burst stimulation (TBS), a new form of repetitive
transcranial magnetic stimulation (rTMS), in 10 healthy participants. The investigators will
measure the effects of both excitatory (intermittent, iTBS) and inhibitory (continuous, cTBS)
TBS applied to the motor cortex, a system that when stimulated produces a readily observable
behavioral response (e.g., movement of a given body regions). In addition to brain activity,
we will assess the effects of TBS on motor responses and pain perception. The goal is to
determine how brain activity and blood flow during tasks and at rest change following the
applications of spaced cTBS and iTBS. Additionally, the aim is to determine the duration of
the spaced TBS effects on brain activity and behavior. This study will provide an
understanding of the functional brain and behavioral changes that occur following spaced TBS
to the motor cortex and has implications for reducing the long treatment schedules associated
with classical rTMS protocols.
Official Title
Establishing Functional Biomarkers for Spaced Theta-Burst Stimulation
Stanford Investigator(s)
Nolan Williams
Associate Professor of Psychiatry and Behavioral Sciences (Major Laboratories & Clinical Translational Neurosciences Incubator) and, by courtesy, of Radiology (Neuroimaging and Neurointervention)
Eligibility
Inclusion Criteria:
- Age 18 or older
- Right-handed
- Agree to having fMRI scan
- Willingness to suspend use of analgesic drugs or cough suppressants for 24 hours prior
to the scans
- Proficiency in English sufficient to complete questionnaires/follow instructions
during fMRI assessments
- US Citizen or resident able to receive payment legally
Exclusion Criteria:
- A medical condition that would contraindicate the use of rTMS
- Any condition that would contraindicate MRI (like ferromagnetic metal in the body)
- Pregnancy or breast feeding
- Any significant neurologic disease, including dementia, multi-infarct dementia,
Parkinson's or Huntington's disease, brain tumor, progressive supranuclear palsy,
seizure disorder, subdural hematoma, multiple sclerosis, history of significant head
trauma
- Current antidepressant use (must be washed out for two weeks prior to starting
protocol)
- Inability to stop taking medication contraindicated with treatment
Intervention(s):
device: continuous Theta Burst Stimulation
device: intermittent Theta Burst Stimulation
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Romina Nejad, M.Sc
650-736-2233