Evaluating the Benefits of Physiologic Insulin Delivery

Inclusion Criteria:

   1. 18-60 years of age

   2. Clinical diagnosis of type 1 diabetes

   3. On insulin pump therapy and continuous glucose monitor (CGM) for at least 3 months

   4. Ability to safely receive intraperitoneal injection

   5. For females, not currently known to be pregnant

   6. Understanding and willingness to follow the protocol and sign informed consent

   7. Ability to speak, read and write in the language of the investigators

Exclusion Criteria:

   1. Diabetic ketoacidosis in the past 3 months

   2. Severe hypoglycemia resulting in seizure or loss of consciousness within 3 months
   prior to enrollment

   3. Pregnant or lactating

   4. Active infection

   5. A known medical condition that in the judgment of the investigator might interfere
   with the completion of the protocol

   6. Known cardiovascular events in the last 6 months

   7. Known seizure disorder

   8. Inpatient psychiatric treatment in the past 6 months

   9. Lack of stability on medication 1 month prior to enrollment including
   antihypertensive, thyroid, anti-depressant or lipid lowering medication.

10. Suspected drug or alcohol abuse

11. Chronic kidney disease (GFR < 60 mL/min/1.73m^2)