©2024 Stanford Medicine
Genicular Artery Embolization (GAE) for Osteoarthritic Knee Pain
Not Recruiting
Trial ID: NCT04472091
Purpose
The objective of this investigation is to evaluate the safety of the geniculate artery
embolization (GAE) procedure with HydroPearl® Microspheres in 30 patients with knee pain
caused by osteoarthritis with 24 months follow-up. The GAE procedure is an arterial
embolization procedure that blocks abnormal blood vessels caused be knee arthritis in order
to evaluate the effect on knee pain.
Official Title
Genicular Artery Embolization for the Treatment of Moderate to Severe Osteoarthritic Knee Pain
Stanford Investigator(s)
Andrew Picel
Clinical Associate Professor, Radiology
Eligibility
Inclusion Criteria:
1. Provide informed consent
2. Age ≥ 40 years
3. Moderate to severe knee pain (VAS >40 mm)
4. Pain refractory to 3 months of conservative treatments, including at least one of the
following:
- a. Anti-inflammatory medications
- b. Physical therapy
- c. Intra-articular injections
5. Kellgren-Lawrence radiographic grade 1, 2, or 3 disease
6. MRI features of active synovitis (synovial thickening and/or enhancement on MRI).
7. Ineligibility or refusal of surgical management.
8. Local knee tenderness
Exclusion Criteria:
1. Rheumatoid or infectious arthritis
2. Advanced lower extremity atherosclerosis that would limit selective angiography
3. Local knee infection
4. Prior knee surgery (excluding arthroscopic/meniscal interventions)
5. Uncorrectable coagulopathy (INR>1.8, platelets<50,000/µL)
6. Iodine allergy resulting in anaphylaxis
7. Chronic renal insufficiency (serum creatinine >2 mg/dL)
8. Life expectancy less than 6 months
Intervention(s):
device: Genicular artery embolization (GAE)
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Andrew C Picel, MD
650-736-6109