Testing the Addition of an Anti-cancer Drug, Hu5F9-G4 (Magrolimab), to the Usual Chemotherapy Treatment (Mogamulizumab) in T-Cell (a Type of Immune Cell) Lymphoma That Has Returned After Treatment or Does Not Respond to Treatment

Inclusion Criteria:

   - Diagnosis of either mycosis fungoides (MF) or Sezary syndrome (SS) by the World Health
   Organization (WHO) 2016 classification (Swerdlow et al., 2017), stage IB-IV by
   modified International Society for Cutaneous Lymphomas (ISCL)/ European Organization
   of Research and Treatment of Cancer (EORTC) classification (Olsen et al., 2011),
   without large cell transformation (LCT) at the time of screening. Patients with a
   history of prior LCT are permitted

   - Patients must have had at least one prior course of systemic therapy

   - Age >= 18 years

      - Because no dosing or adverse event data are currently available on the use of
      Hu5F9-G4 (magrolimab) in combination with mogamulizumab in patients <18 years of
      age, children are excluded from this study, but will be eligible for future
      pediatric trials

   - Eastern Cooperative Oncology Group (ECOG) performance status =< 2 (Karnofsky >= 60%)

   - Hemoglobin >= 9.5 g/dL and transfusion independence (defined as not requiring more
   than 2 units of red blood cell [RBC] transfusions during the 4-week period prior to
   screening)

   - Absolute neutrophil count >= 1,000/mcL

   - Platelets >= 75,000/mcL

   - Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) except for subjects
   with Gilbert's syndrome or genetic equivalent

   - Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase
   [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT])
   =< 3 x institutional ULN

   - Glomerular filtration rate (GFR) >= 40 mL/min/1.73 m^2 by the Cockcroft-Gault formula

   - Patients must meet the following minimum wash-out window from previous treatments to
   the first treatment

      - >= 3 weeks for systemic anti-cancer therapies

      - >= 2 weeks for phototherapy, local radiation therapy, topical high potency
      corticosteroid, topical retinoid, topical nitrogen mustard, or topical toll-like
      receptor (TLR)-agonist

      - >= 12 weeks for total skin electron beam therapy Participants with rapidly
      progressive malignant disease may be enrolled prior to completion of the above
      periods with approval of the protocol director

   - Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral
   therapy with undetectable viral load within 6 months are eligible for this trial

   - For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral
   load must be undetectable on suppressive therapy, if indicated

   - Patients with a history of hepatitis C virus (HCV) infection must have been treated
   and cured. For patients with HCV infection who are currently on treatment, they are
   eligible if they have an undetectable HCV viral load

   - Patients with treated brain metastases are eligible if follow-up brain imaging after
   central nervous system (CNS)-directed therapy shows no evidence of progression for a
   minimum of 3 months

   - Patients with a prior or concurrent malignancy whose natural history or treatment does
   not have the potential to interfere with the safety or efficacy assessment of the
   investigational regimen are eligible for this trial

   - The effects of Hu5F9-G4 (magrolimab) on the developing human fetus are unknown. For
   this reason and because monoclonal antibody agents as well as other therapeutic agents
   used in this trial (mogamulizumab) are known to be teratogenic, women of child-bearing
   potential and men must agree to use adequate contraception (hormonal or barrier method
   of birth control; abstinence) prior to study entry and for the duration of study
   participation and continue for 4 months after the last dose of both Hu5F9-G4
   (magrolimab) and mogamulizumab. Effective contraception is defined as oral
   contraceptives, double barrier method (condom plus spermicide or diaphragm plus
   spermicide) or practice true abstinence from heterosexual intercourse. Women of
   childbearing potential includes any female who has experienced menarche and has not
   undergone successful surgical sterilization or is not postmenopausal (defined as
   amenorrhea >= 12 consecutive months). Should a woman become pregnant or suspect she is
   pregnant while she or her partner is participating in this study, she should inform
   her treating physician immediately. Men treated or enrolled on this protocol who are
   sexually active with women of childbearing potential and who have not had vasectomies
   must also agree to use adequate contraception prior to the study, for the duration of
   study participation, and 4 months after completion of Hu5F9-G4 (magrolimab)
   administration

   - Female patients of childbearing potential must not be nursing or planning to be
   pregnant and must have a negative urine or serum pregnancy test within 30 days before
   randomization and within 72 hours before the first administration of study treatment

      - Female patients of childbearing potential must be willing to use one highly
      effective method of contraception during the study and continue for 4 months
      after the last dose of study treatment

      - Male patients who are sexually active with a woman of childbearing potential
      (WOCBP) and who have not had vasectomies must be willing to use a barrier method
      of contraception (condom plus spermicidal gel) and refrain from sperm donation
      during the study and for 4 months after the last dose of study treatment. If the
      partner is pregnant, male patients must use barrier method contraception (condom)
      during the study and for 4 months after the last dose of study treatment to
      prevent fetal exposure to study treatment

   - Ability to understand and the willingness to sign a written informed consent document.
   Participants with impaired decision-making capacity (IDMC) who have a
   legally-authorized representative (LAR) and/or family member available will also be
   eligible

   - Willing to comply with clinic visit schedule and procedures including mandatory
   biopsies

Exclusion Criteria:

   - Prior treatment with Hu5F9-G4 (magrolimab) or any agent targeting CD47-SIRPalpha

   - Prior progression of disease with mogamulizumab

   - Patients who have not recovered from adverse events due to prior anti-cancer therapy
   (i.e., have residual toxicities > grade 1) with the exception of alopecia and
   lymphopenia (any grade permitted). Residual peripheral neuropathy must have improved
   to grade 2 or better

   - Patients who are receiving any other investigational agents

   - Allogeneic hematopoietic stem cell transplant recipients with any graft-versus-host
   disease within the previous 3 months or requiring immunosuppression

   - Active autoimmune disease that has required systemic immunosuppressive medication
   within the previous 3 months

   - Active herpes simplex or herpes zoster. Subjects on prophylaxis for herpes who have no
   active signs of active infection, and whose last active infection was more than 6
   months ago, may enter the study, and should continue to take the prescribed medication
   for the duration of the study

   - History of allergic reactions attributed to compounds of similar chemical or biologic
   composition to Hu5F9-G4 (magrolimab), other monoclonal antibodies, or other agents
   (mogamulizumab) used in study

   - Significant cardiopulmonary disease defined as

      - Acute myocardial infarction within the last 6 months

      - Unstable angina

      - Congestive heart failure New York Heart Association (NYHA) class III-IV

   - Patients with uncontrolled intercurrent illness requiring antibiotics. Patients on
   prophylactic antibiotics for non-complicated staphylococcus colonization/infection are
   eligible

   - Patients with new or progressive brain metastases (active brain metastases) or
   leptomeningeal disease are excluded

   - Patients with psychiatric illness/social situations or substance abuse that would
   limit compliance with study requirements

   - Pregnant women are excluded from this study because Hu5F9-G4 (magrolimab) is
   monoclonal antibody agent with the potential for teratogenic or abortifacient effects.
   Because there is an unknown but potential risk for adverse events in nursing infants
   secondary to treatment of the mother with Hu5F9-G4 (magrolimab), breastfeeding should
   be discontinued if the mother is treated with Hu5F9-G4 (magrolimab). These potential
   risks may also apply to other agents used in this study (mogamulizumab)

   - Patients with RBC transfusion dependence, defined as requiring more than 2 units of
   RBCs transfused during the 4-week period prior to screening. RBC transfusions are
   permitted during the screening period and prior to enrollment

   - Patients with prior autoimmune thrombocytopenia, hemolytic anemia or Evans syndrome
   requiring treatment in the last 12 months

   - Patients on the following medications at the time of enrollment:

      - Immunotherapy or immunosuppressive drugs (e.g. chemotherapy or systemic
      corticosteroids) EXCEPT for the following:

         - Intranasal, inhaled, or local steroid injection (e.g. intra-articular
         injection)

         - Systemic corticosteroids at physiologic doses =< 10 mg/day of prednisone or
         equivalent, if patient has been on a stable dose for at least 2 weeks prior
         to the first treatment

         - Low and medium potency topical corticosteroids are permitted if patient has
         been on a stable dose for at least 2 weeks prior to the first treatment

         - Steroids as premedication for hypersensitivity reactions (e.g. computed
         tomography [CT] scan premedication)

      - Growth factors (granulocyte colony stimulating factor or granulocyte macrophage
      colony stimulating factor) EXCEPT for erythropoietin and darbepoetin alpha

      - Herbal remedies with immunostimulating properties (e.g., mistletoe extract) or
      known to potentially interfere with major organ function (e.g. hypericin)

   - Live vaccines are not allowed while participating in the trial. Examples of live
   vaccines include, but are not limited to, the following: measles, mumps, rubella,
   chicken pox, yellow fever, rabies, Bacillus Calmette-Guerin (BCG), typhoid (oral)
   vaccine, and intranasal influenza vaccines (e.g., Flu-Mist). However, seasonal
   influenza vaccines for injection are generally killed virus vaccines and are allowed