Trial Search Results

Magnesium for Peroral Endoscopic Myotomy

Postoperative pain after peroral endoscopic myotomy occurs due to involuntary esophageal smooth muscle spasms. Magnesium has antispasmodic properties as a smooth muscle relaxant. This study hypothesizes that among patients having peroral endoscopic myotomy, magnesium will reduce the incidence of postoperative pain while decreasing perioperative opioid requirements.

Stanford is currently accepting patients for this trial.

Lead Sponsor:

Stanford University


  • Drug: Magnesium sulfate
  • Drug: Normal Saline


Phase 2


Inclusion Criteria:

- Planned peroral endoscopic myotomy procedure

Exclusion Criteria:

   - cannot give consent

   - patients who are clinically unstable and/or require urgent/emergent intervention

   - previous esophageal myotomy

   - preexisting hypermagnesemia

   - end-stage renal disease

   - neuromuscular disease, including but not limited to Guillain-Barre syndrome,
   myasthenia gravis, congenital myopathy, and muscular dystrophy

   - preexisting heart failure

   - severe ventricular systolic dysfunction (left or right ventricle)

Ages Eligible for Study

18 Years - N/A

Genders Eligible for Study


Now accepting new patients

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Richard K Kim, MD
Not Recruiting