Neural Circuit Biomarkers of Transcranial Magnetic Stimulation Study

Inclusion Criteria:

   - Ages 18 years and older

   - Meets Diagnostic and Statistical Manual edition 5 (DSM-5) criteria for Major
   Depressive Disorder (MDD) (as documented by the treating physician)

   - Meet study criteria for pharmacoresistance in accordance with the Clinical
   transcranial magnetic stimulation (TMS) Program (i.e. failed at least one
   antidepressant in the current episode)

   - Ability to obtain a motor threshold (MT) prior to the start of treatment

   - Stable medical conditions and ability to maintain stability on current medication
   regimen for the duration of treatment

   - Ability to participate in a daily treatment regimen

   - Able to read, verbalize understanding, and voluntarily sign the Informed Consent Form
   prior to participating in any study-specific procedures or assessments

Exclusion Criteria:

   - History of seizure disorder

   - Structural or neurologic abnormalities present or in close proximity to the treatment
   site

   - History of brain surgery

   - Pacemaker or medical infusion device (unless magnetic resonance imaging compatible)

   - History of traumatic brain injury within 60 days of the start of treatment

   - Severe or uncontrolled alcohol or substance use disorders

   - Active withdrawal from alcohol or substances

   - Implanted device in the head

   - Metal in the head

   - Severe impediment to vision, hearing and/or hand movement, likely to interfere with
   ability to complete the assessments, or unable and/or unlikely to follow the study
   protocols

   - Lifetime history of bipolar I disorder

   - Inability to speak, read or understand English

   - Plans to move out of the area during the study period

   - Clinician and/or Investigator discretion for clinical safety or protocol adherence