A Study of AL102 in Patients With Progressing Desmoid Tumors

Inclusion Criteria Part A:

   1. At least 18 years of age (inclusive) at the time of signing the ICF.

   2. Histologically confirmed desmoid tumor (aggressive fibromatosis) by local pathologist
   (prior to informed consent).

   3. Disease progression, assessed locally by the investigator, defined as having at least
   one of the following:

      - Unidimensional growth of desmoid tumor(s) by ≥10%, using the sum of the largest
      diameters of target lesion(s), within 18 months of the screening MRI

      - Having desmoid tumor-related pain that is not adequately controlled with
      nonopioid medication

   4. At least 1 measurable lesion amenable to volume measurements by MRI at screening (Part
   A only)

   5. One of the following:

      - Treatment naïve subjects for whom, in the opinion of the investigator, the IP is
      deemed appropriate, OR

      - Recurrent/refractory disease following at least one line of therapy (including
      surgery, radiation, or systemic therapy)

   6. Agrees to provide formalin-fixed paraffin embedded archival or fresh tumor tissue for
   re- confirmation of disease.

   7. Must be able to swallow whole capsules with no GI condition affecting absorption;
   nasogastric or G-tube administration is not allowed.

Exclusion Criteria Part A:

   1. Diagnosed with a malignancy in the past 2 years with some exceptions.

   2. Current or recent (within 2 months of IP administration) GI disease or disorders that
   increase the risk of diarrhea, such as inflammatory bowel disease and Crohn's disease.

   3. Evidence of uncontrolled, active infection, requiring systemic anti-bacterial,
   anti-viral or anti- fungal therapy ≤7 days prior to administration of IP such as known
   active infection with hepatitis B, hepatitis C, or human immunodeficiency virus (HIV)
   at Screening.

   4. Myocardial infarction within 6 months prior to enrollment, greater than Class 1 angina
   pectoris, or has New York Heart Association (NYHA) Class III or IV heart failure, ,
   symptomatic ventricular arrhythmias, sustained ventricular tachycardia, Torsade's de
   Pointes (TdP), the long QT syndrome, pacemaker dependence, or electrocardiographic
   evidence of acute ischemia.

   5. Unstable or severe uncontrolled medical condition (e.g., unstable cardiac or pulmonary
   function or uncontrolled diabetes) or any important medical illness or abnormal
   laboratory finding that would, in the investigator's judgment, increase the risk to
   the subject associated with his or her participation in the study.

   6. Pregnant or breastfeeding or expecting to conceive children within the projected
   duration of the study.

   7. Eastern Cooperative Oncology Group (ECOG) performance status ≥2

   8. Abnormal organ and marrow function at Screening defined as:

      1. Neutrophils <1000/mm3,

      2. Platelet count <100,000/mm3,

      3. Hemoglobin <9 g/dL,

      4. Total bilirubin >1.5x upper limit of normal (ULN) (except known Gilbert's
      syndrome),

      5. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) >2.5x ULN,

      6. Serum creatinine > ULN and creatinine clearance (CrCl) <60 mL/min (calculation of
      CrCl will be based on acceptable institution standard)

      7. Uncontrolled triglyceride ≥Grade 2 elevations per common terminology criteria for
      adverse events (CTCAE) v5.0 (>300 mg/dL or >3.42 mmol/L).

   9. ECG Exclusions (Part A only)

      1. Mean QT interval corrected for heart rate using Fridericia's formula (QTcF) ≥450
      msec.

      2. QRS duration > 110 ms

      3. PR interval > 240 ms

      4. Marked ST-T wave abnormalities which would make it difficult to measure the QT
      interval

10. Any treatments for desmoid tumors within 4 weeks prior to first dose of
   investigational therapy; subject must have recovered from therapy related toxicity to
   < CTCAE Grade 2 or clinical baseline. Therapy includes:

      1. Locoregional tumor directed therapies such as major surgery, radiation,
      radiofrequency ablation, or cryosurgery

      2. Systemic therapy including chemotherapy, biologic (anti-neoplastic agent,
      antibodies), TKIs (e.g., sorafenib, pazopanib, imatinib), hormonal therapy, or
      investigational therapy

11. Chronic NSAIDs for the treatment of desmoid tumors within 4 weeks of first dose of IP;

Inclusion Criteria Part B

   1. ≥12 years of age (inclusive) and ≥ 40 kg at the time of signing the ICF.

   2. Histologically confirmed desmoid tumor (aggressive fibromatosis) by local pathologist
   (prior to informed consent) that has progressed by ≥ 20% as measured by RECIST v1.1
   within 12 months of the screening visit scan.

   3. Evidence of measurable disease by CT/MRI scan. Measurable lesions are defined
   according to RECIST v1.1.

   4. Subject and/or legally authorized representative (i.e. parent/guardian) must be
   capable of giving signed informed consent, which includes compliance with the
   requirements and restrictions listed in the ICF.

   5. Minor subjects must be capable of giving written assent as appropriate per the
   applicable age (per local regulatory requirements).

For all other inclusion criteria refer to Part A inclusion criteria.

Exclusion Criteria Part B The subjects must be excluded from participating in the study if
they meet any of the exclusion criteria for Part A, except where otherwise noted.