Journey Study: Evaluate the Efficacy, Safety, and Tolerability of Valbenazine as Adjunctive Treatment for Schizophrenia

Inclusion Criteria:

• Participants must meet all of the following inclusion criteria:

   1. Completed written informed consent.

   2. At the time of signing the informed consent, participant must be ≥18 years of age

   3. Medically confirmed diagnosis of schizophrenia as defined by the Diagnostic and
   Statistical Manual of Mental Disorders (DSM-5).

   4. The initial diagnosis of schizophrenia must be ≥1 year before the screening visit.

   5. Plasma levels for at least 1 of the participant's antipsychotic medications must be
   detectable by an available assay.

   6. The participant is treated with a stable regimen antipsychotic medication.

   7. Must meet all of the following criteria at the screening visit and Day 1:

      - PANSS total score ≥70

      - PANSS score of ≥4 on at least 1 of the following:

         - P1 (delusions)

         - P3 (hallucinations)

         - P6 (suspiciousness)

         - G9 (unusual thought content)

      - CGI-S score ≥4

      - Stable background antipsychotic medication dose between the screening visit and
      Day 1

      - Stable PANSS total score between the screening visit and Day 1

   8. The participant is outpatient with stable symptomatology

   9. The participant must have an adult informant (for example, a family member, relative,
   partner, social worker, caseworker, residential facility staff, or nurse).

10. Female participants of childbearing potential must agree to use contraception
   consistently from the screening visit until 30 days after the last dose of study drug
   or final study visit, whichever is longer.

11. Male participants must agree to use contraception consistently from screening until 30
   days after last dose of study treatment.

Exclusion Criteria:

   - Participants will be excluded from the study if they meet any of the following
   criteria:

      1. Pregnant or breastfeeding or plans to become pregnant during the study. This
      criterion must be reconfirmed prior to the first dose of study treatment on Day
      1.

      2. Known hypersensitivity to any component of the formulation of valbenazine.

      3. Has history of treatment resistant schizophrenia.

      4. Evidence of depression as measured by a Calgary Depression Scale for
      Schizophrenia (CDSS) score ≥11 at the screening visit or Day 1.

      5. Participants with any suicidal behavior or suicidal ideation within 6 months
      before the screening visit or Day 1.

      6. Diagnosis of moderate or severe substance use disorder within the 6 months before
      the screening visit.

      7. Have a clinically significant unstable medical condition within 60 days before
      the screening visit in the judgement of the investigator or any laboratory value
      outside the normal range that is considered by the investigator to be clinically
      significant at the screening visit.

      8. Prior (within 6 months of the screening visit) or concomitant use of any VMAT2
      inhibitor.