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International REgistry of COnservative or Radical Treatment of Localized Kidney Tumors
Recruiting
I'm InterestedTrial ID: NCT05363657
Purpose
Partial nephrectomy (PN) is the standard treatment for localized renal masses and should be
preferred in clinical T1 (<7 cm tumor diameter) renal tumors over radical nephrectomy (RN)
whenever technically feasible. Nonetheless, indications, approaches, techniques for PN, and
correct reporting of outcomes, are still a matter of great debate within the urology
community. Concurrently, case-report series suggested that alternative strategies for the
treatment of localized renal tumors (ablation techniques (AT), watchful waiting (WW), active
surveillance (AS)) could be feasible with acceptable oncologic outcomes in particular
settings of patients with localized renal tumors. In this complex clinical scenario, the role
surgeon-related and environmental factors (such as surgical experience, hospital resources,
countries' social background and performance of health system) are important to address the
best personalized approach in patients with renal tumors.
In the light of current evidence, many unsolved questions still remain and many unmet needs
must be addressed. In particular, 1) the risk-benefit trade-offs between PN and RN for
anatomically complex renal localized tumors; 2) the definition of evidence-based strategies
to tailor the management strategy (AT vs WW vs AS vs surgery) in different subset of patients
with particular clinical conditions (i.e. old, frail, comorbid patients); and 3) the
definition of evidence-based recommendations to adapt surgical approach (open vs laparoscopic
vs robotic) and resection techniques to different patient-, tumor-, and surgeon-specific
characteristics.
To meet the challenges, to overcome the limitations of current kidney cancer literature (such
as the retrospective study design, potential risk of biases, and heterogeneous follow-up of
most series), and to provide high-quality evidence for future development of effective
clinical practice Guidelines, we designed the international REgistry of COnservative or
Radical treatment of localized kiDney tumors (i-RECORD) Project.
The expected impact of the i-RECORD project is to provide robust evidence on the leading
clinical and environmental factors driving selection of the management strategy in patients
with kidney cancer, and the differential impact of different management strategies (including
AS, WW, AT, PN and RN) on functional, perioperative and oncological outcomes, as well as
quality of life assessment, at a mid-long term follow-up (5-10 years).
Official Title
International REgistry of COnservative or Radical Treatment of Localized Kidney Tumors (i-RECORd)
Stanford Investigator(s)
Benjamin I. Chung
Associate Professor of Urology
Eligibility
Inclusion Criteria:
- Radiological diagnosis of renal tumor susceptible to active treatment or AS/WW.
- Age ≥18 years
- Informed consent signed
Exclusion Criteria:
- Patient refuse to participate in clinical research.
- Urothelial renal carcinoma.
Intervention(s):
procedure: Partial Nephrectomy (PN)
procedure: Radical Nephrectomy (RN)
procedure: Ablation therapy (AT)
diagnostic test: Active Surveillance (AS)
Recruiting
I'm InterestedContact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Satvir Basran
sbasran@stanford.edu