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A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell (CD19 CAR T) Therapy, in Subjects With Refractory Lupus Nephritis
Recruiting
I'm InterestedTrial ID: NCT05938725
Purpose
A Study of Anti-CD19 Chimeric Antigen Receptor T Cell Therapy for Subjects With Refractory
Lupus Nephritis
Official Title
A Phase 1/2, Open-Label, Multicenter Study of KYV-101, an Autologous Fully-Human Anti-CD19 Chimeric Antigen Receptor T-Cell (CD19 CAR T) Therapy, in Subjects With Refractory Lupus Nephritis (KYSA-1)
Stanford Investigator(s)
Richard Lafayette
Professor of Medicine (Nephrology)
Eligibility
Inclusion Criteria:
1. Age ≥18 years
2. Clinical diagnosis of SLE according to 2019 European League Against
Rheumatism/American College of Rheumatology (EULAR/ACR) classification criteria
3. Biopsy-proven proliferative LN Class III or IV according to 2018 International Society
of Nephrology/Renal Pathology Society (ISN/RPS) criteria
4. Positive anti-nuclear antibody (ANA) (titer ≥1:80 ), anti-dsDNA (≥30 IU/mL on
enzyme-linked immunosorbent assay [ELISA]), or anti-Smith at screening or by
documented medical history
5. Up to date on recommended vaccinations, including against coronavirus disease 2019
(COVID-19)/ severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), per Centers
for Disease Control and Prevention (CDC) or institutional guidelines for immune
compromised individuals
Exclusion Criteria:
1. Rapidly progressive glomerulonephritis; history of or currently active severe central
nervous system (CNS) lupus, including cerebritis, cerebrovascular accident, and
seizures
2. Prior treatment with cellular immunotherapy (CAR-T) or gene therapy product directed
at any target
3. History of allogeneic or autologous stem cell transplant
4. Evidence of active hepatitis B or hepatitis C infection
5. Positive serology for HIV
6. Primary immunodeficiency
7. History of splenectomy
8. History of stroke, seizure, dementia, Parkinson's disease, coordination movement
disorder, cerebellar diseases, psychosis, paresis, aphasia, and any other neurologic
disorder investigator considers would increase the risk for the subject
9. Impaired cardiac function or clinically significant cardiac disease
10. Previous or concurrent malignancy with the following exceptions:
1. Adequately treated basal cell or squamous cell carcinoma (adequate wound healing
is required prior to screening)
2. In situ carcinoma of the cervix or breast, treated curatively and without
evidence of recurrence for at least 3 years prior to screening
3. A primary malignancy which has been completely resected, or treated, and is in
complete remission for at least 5 years prior to screening
Intervention(s):
biological: KYV-101 anti-CD19 CAR-T cell therapy
drug: Standard lymphodepletion regimen
Recruiting
I'm InterestedContact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Kamand Shafieha
650-498-3025