©2024 Stanford Medicine
Investigating the Neural Mechanisms of Repetitive Brain Stimulation With Invasive and Noninvasive Electrophysiology in Humans
Not Recruiting
Trial ID: NCT05996900
Purpose
Transcranial magnetic stimulation (TMS) is an effective treatment for depression, but
clinical outcome is suboptimal, partially because investigators are missing
biologically-grounded brain markers which show that TMS is modifying activity at the intended
target in the brain. The goal of this proposal is to characterize the key markers of the
brain's response to repeated doses of TMS with high resolution using invasive brain
recordings in humans, and relate these brain markers to noninvasive recordings. These markers
will improve the understanding of TMS and can be used to optimize and enhance clinical
efficacy for depression and other psychiatric disorders.
Official Title
Investigating the Neural Mechanisms of Repetitive Brain Stimulation With Invasive and Noninvasive Electrophysiology in Humans
Stanford Investigator(s)
Eligibility
Inclusion Criteria:
- Men and women, ages 18 to 65
- Medication-refractory epilepsy requiring phase II monitoring
- Must have intellectual capacity to ensure adequate comprehension of the study and
potential risks involved in order to provide informed consent
- No current or history of major neurological disorders other than epilepsy
Exclusion Criteria:
- Those with a contraindication for MRIs (e.g. implanted metal)
- Any unstable medical condition
- Neurological or uncontrolled medical disease
- Active substance abuse
- Currently pregnant or breastfeeding
Intervention(s):
device: Intracranial electrodes
device: TMS
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Jade Truong
(408) 840-3313