Personalized Accelerated ChEmoRadiation (PACER) for Lung Cancer

Inclusion Criteria:

   - Histologically or cytologically documented malignancy of the lung including non-small
   cell lung cancer or small cell lung cancer planned for definitive therapy with
   fractionated radiation (60-66 Gy) and concurrent systemic therapy

   - ECOG performance status of 0-2

   - Age > 18 years old

   - Ability to understand and the willingness to personally sign the written IRB approved
   informed consent document

   - Estimated life expectancy of 12 weeks or longer

Exclusion Criteria:

   - Contraindication to receiving radiotherapy or systemic therapy as determined by
   treating radiation and medical oncologist

   - Age < 18 years old

   - Tumor directly invading the major pulmonary arteries, aorta, heart or proximal
   bronchial tree

   - Diagnosis of interstitial pulmonary fibrosis

   - Previous radiation therapy to the thorax that would result in overlapping high dose
   radiation fields