5-Day Preoperative Radiation for Soft Tissue Sarcoma

Inclusion Criteria:

   1. Histologically confirmed soft tissue sarcoma of the extremity, trunk or
   retroperitoneum.

   2. Has been offered preoperative radiation and surgery as part of standard-of-care
   treatment

   3. Age ≥ 18

   4. KPS ≥ 70 or ECOG 0 to 2

   5. Life expectancy ≥ 6 months

   6. If a woman is of childbearing potential, a negative serum or urine pregnancy test must
   be documented.

   7. Ability to understand and the willingness to personally sign the written IRB approved
   informed consent document.

Exclusion Criteria:

   1. History of prior radiation to the area to be treated.

   2. Active use of other anti-cancer investigational agents.

   3. Planned use of concurrent chemotherapy, targeted therapy, or immunotherapy with
   radiation therapy (defined as the time interval starting 1 week before the first and
   last fraction of radiation therapy and surgery).

   4. Pregnancy.