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A Study of Participants With Cerebral Adrenoleukodystrophy (CALD) Treated With Elivaldogene Autotemcel
Recruiting
Trial ID: NCT06224413
Purpose
The main aim of this study is to assess and describe the safety outcomes, including newly
diagnosed malignancies, of patients with CALD treated with eli-cel in the post-marketing
setting (tradename Skysona) and to describe major functional disability (MFD)-free survival
over time in participants with more advanced early active CALD. All enrolled participants
with CALD treated with eli-cel in the post-marketing setting will be followed in this study
for 15 years. No investigational drug product will be administered in this study. This study
will enroll 120 participants with CALD treated with eli-cel in the post-marketing setting. A
subpopulation of 24 participants with more advanced early active CALD will be specifically
enrolled as required by the US FDA as a condition of accelerated approval and will be
considered as a separate cohort for effectiveness outcomes.
Official Title
A Postmarketing, Prospective, Multicenter, Observational, Long-Term Safety and Effectiveness Registry Study of Patients With Cerebral Adrenoleukodystrophy (CALD) Treated With Elivaldogene Autotemcel (Stargazer)
Stanford Investigator(s)
Eligibility
Inclusion Criteria:
Participants who fulfill the following criteria will be eligible for inclusion in this
Registry Study.
- Participant must be treated with eli-cel in the post marketing setting at a center in
the United States (US) that participates in the Registry Study.
- Participant must have provided an informed consent and/or assent to participate in
Center for International Blood and Marrow Transplant Research (CIBMTR) registry.
- Participant must have provided an informed consent and/or assent to participate in the
Registry Study.
- Participant must receive follow up care by a US-based physician with the ability to
submit REG-502 data.
Registry Study Subpopulation inclusion:
Twenty-four of the 120 patients in the Registry Study must meet the following inclusion
criteria which will be used to create the more advanced early active CALD subpopulation:
• Participant must meet the above inclusion criteria and have a Loes score of 4.5 through
9.0 with GdE+ (gadolinium enhancement positivity) from an MRI performed before treatment
with eli-cel and with NFS of 0 or 1 at baseline.
Exclusion Criteria:
There are no exclusion criteria for this Registry Study.
Intervention(s):
other: No Intervention
Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305