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68Ga-PSMA PET/CT in Detecting Prostate Cancer Recurrence in Patients With Elevated PSA After Initial Treatment
Not Recruiting
Trial ID: NCT02673151
Purpose
The purpose of this research study is to see if recurrent prostate cancer can be identified
using a special procedure called a positron emission tomography (PET) scan. PET/CT is used to
describe information regarding the function, as well as location and size of a tumor.
Official Title
68-Ga PSMA 11 PET/CT for Detection of Recurrent Prostate Cancer After Initial Therapy in Patients With Elevated PSA
Stanford Investigator(s)
Andrei Iagaru
Professor of Radiology (Nuclear Medicine)
Eligibility
Inclusion Criteria:
- Histopathological proven prostate adenocarcinoma
- Rising prostate-specific antigen (PSA) after definitive therapy with prostatectomy or
radiation therapy (external beam or brachytherapy)
- Post radical prostatectomy (RP) - American Urology Association (AUA)
recommendation
- PSA greater than 0.2 ng/mL measured 6 to 13 weeks after RP
- Confirmatory persistent PSA greater than 0.2 ng/mL (total of two PSA
measurements greater than 0.2 ng/mL)
- Post-radiation therapy -American Society for Radiation Oncology (ASTRO)-Phoenix
consensus definition
- A rise of PSA measurement of 2 or more ng/mL over the nadir
- Karnofsky performance status of ≥ 50 (or Eastern Cooperative Oncology Group [ECOG] /
World Health Organization [WHO] equivalent)
- Able to provide written consent
Exclusion Criteria:
- Investigational therapy for prostate cancer.
- Unable to lie flat, still or tolerate a positron emission tomograpy (PET) scan.
- Prior history of any other malignancy within the last 2 years, other than skin basal
cell or cutaneous superficial squamous cell carcinoma that has not metastasized and
superficial bladder cancer.
Intervention(s):
procedure: Computed Tomography (CT) scan
drug: 68Ga-PSMA-11
procedure: Positron Emission Tomography (PET)
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
David Marcellus
650-723-4547