Aromatase Inhibitor Growth Study: Letrozole vs. Anastrozole

Not Recruiting

Trial ID: NCT02137538

Age - 10 Years-17 Years Gender - Male Accepting Healthy Volunteers - No

Purpose

The purpose of the study is to determine if there are differences in the final height or hormone profile of short pubertal boys placed on different forms of aromatase inhibitor now routinely used to increase stature: Anastrozole and Letrozole. It also should determine if there are differences in the side effect profiles of the two drugs to be used.

Official Title

Randomization to Letrozole vs. Anastrozole in Short Pubertal Males

Stanford Investigator(s)

Laura K. Bachrach

Eligibility


Inclusion Criteria:

   - Current height less than 5th percentile AND/OR

   - Predicted adult height (based on bone age) more than 10 cm below target height (mid
   parental height)

   - Evidence of puberty: physical signs and serum luteinizing hormone > 0.3 IU/L and
   testosterone > 15 ng/dl

Exclusion Criteria:

   - Bone age reading more than 14.0 years

   - Follicle stimulating hormone > 20 IU/L

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Intervention(s):

drug: Letrozole

drug: Anastrozole

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
E Kirk Neely, MD
650-723-5791

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