A Prospective, Contralateral, Eye to Eye Comparison of SMILE Surgery to LASIK Surgery

Not Recruiting

Trial ID: NCT03067077


Subjects will undergo SMILE surgery in one eye and LASIK surgery in their other eye to correct myopia.

Official Title

A Prospective, Randomized Comparison of SMILE Surgery to Wavefront-guided LASIK Surgery

Stanford Investigator(s)

Edward Manche, MD
Edward Manche, MD

Professor of Ophthalmology


Inclusion Criteria:

   - Subjects age 22 and older with healthy eyes. Nearsightedness between -0.75 diopters
   and -8.00 diopters.

   - Subjects with up to 3.00 diopters of astigmatism.

Exclusion Criteria:

   - Subjects under the age of 22.

   - Subjects with excessively thin corneas.

   - Subjects with topographic evidence of keratoconus.

   - Subjects with ectatic eye disorders.

   - Subjects with autoimmune diseases.

   - Subjects who are pregnant or nursing.

   - Subjects must have similar levels of nearsightedness in each eye. They can not be more
   than 1.5 diopter of difference between eyes.

   - Subjects with 3.25 or more diopters of astigmatism

   - Subjects must have similar levels of astigmatism in each eye. They can not have more
   than 0.50 diopters of difference between eyes.


procedure: SMILE

procedure: LASIK

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Edward E Manche, MD