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Assessing the Endometrial Environment in Recurrent Pregnancy Loss and Unexplained Infertility
Not Recruiting
Trial ID: NCT03401918
Purpose
The purpose of this study is to determine if patients with recurrent pregnancy loss or
unexplained infertility have an altered uterine gene expression or uterine microbiome
(micro-organism composition) during the window of embryo implantation. Furthermore we would
like to assess for women with an abnormal uterine gene expression whether vaginal
progesterone medication improves or alters gene expression and for women with an abnormal
microbiome whether antibiotic treatment followed by probiotic treatment normalizes the
microbiome.
Official Title
Assessing the Endometrial Environment in Recurrent Pregnancy Loss and Unexplained Infertility
Stanford Investigator(s)
Ruth Lathi, M.D.
Professor of Obstetrics and Gynecology (Reproductive Endocrinology and Infertility)
Eligibility
Inclusion/Exclusion Criteria:
1. Recurrent Pregnancy Loss
Inclusion:
- Age 18-45
- 3 or more SABs including biochemical pregnancies OR 2 or more SABs if one is
documented to be euploid
Exclusion:
- irregular menstrual cycles
- Submucosal fibroid >3cm
- Stage 3-4 endometriosis
- BMI >40
- IUD within the last 3 months
2. Unexplained infertility Patients
Inclusion:
- TTC x >= 1 year
- At least one SA with TMS >10 mil within last 2 years
- At least one patent fallopian tube documented by HSG or SHG
- Cycle length 25-35 days
Exclusion:
- Irregular menstrual cycles
- Submucosal fibroid >3cm
- Stage 3-4 endometriosis
- BMI >40
- IUD within the last 3 months
- Less then 2 SABs including biochemical pregnancies
3. Healthy control patients
Inclusion:
- Patients who present for fertility preservation, sex selection, same sex couples
needing fertility care, preconception counseling
- 1 or more live births
Exclusion:
- Irregular menstrual cycles
- Submucosal fibroid >3cm
- Stage 3-4 endometriosis
- BMI >40
- IUD within the last 3 months
- Less then 2 SABs including biochemical pregnancies
- No history of RPL or infertility
Intervention(s):
diagnostic test: Uterine ERA and microbiome testing
drug: Oral antibiotics and vaginal probiotics
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Sara J Churchill, MD
617-513-4997