A Study of XmAb®18087 in Subjects With NET and GIST

Not Recruiting

Trial ID: NCT03411915


This is a Phase 1, multiple dose, ascending dose escalation study; to define a MTD/RD and regimen consisting of a first "priming" dose and escalated subsequent doses of XmAb18087; to describe safety and tolerability; to assess PK and immunogenicity; and to preliminarily assess anti-tumor activity of XmAb18087 in subjects with advanced NET or GIST. The study will enroll dosing cohorts to establish a MTD/RD and regimen in subjects with advanced NET or GIST, then enroll additional subjects into separate NET and GIST expansion cohorts to collect additional data on safety and potential efficacy of XmAb18087.

Official Title

A Phase 1 Multiple Dose Study to Evaluate the Safety and Tolerability of XmAb®18087 in Subjects With Advanced Neuroendocrine and Gastrointestinal Stromal Tumors (DUET-1)

Stanford Investigator(s)

George A. Fisher Jr.
George A. Fisher Jr.

Colleen Haas Chair in the School of Medicine


Inclusion Criteria:

   - Histologically or cytologically confirmed well differentiated low or intermediate
   grade (World Health Organization [WHO] Grade 1 or 2) NET of pancreatic,
   gastrointestinal, lung, or undetermined origin that is locally advanced or metastatic
   and has progressed within the past 12 months

   - Histologically confirmed GIST that is locally advanced or metastatic

   - NET and GIST tumors must be unresectable

   - NET subjects must have progressed on or been ineligible for treatment with
   somatostatin analogues (SSA) and at least one other FDA-approved targeted therapy
   (everolimus or sunitinib).

   - GIST subjects must have previously received all FDA-approved therapies (imatinib
   mesylate, sunitinib malate, and regorafenib) for which they are eligible

   - Must have disease measurable by RECIST 1.1 criteria using either computed tomography
   (CT) or magnetic resonance imaging (MRI) scan

   - Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1

Exclusion Criteria:

   - Diagnosis of high-grade (WHO Grade 3) or poorly differentiated NET; high-grade
   neuroendocrine carcinoma; large cell neuroendocrine carcinoma, small cell carcinoma,
   or mixed small and large cell carcinoma.

   - Subjects currently receiving anti-cancer therapies (other than SSAs, which may

   - Subjects who have received anti-cancer therapies within 2 weeks of the start of study
   drug (including chemotherapy, radiation therapy, immunotherapy, etc.).

   - Must not be experiencing a Grade 3 or 4 toxicity from previous anti-cancer treatment

   - Must not be receiving other anti-cancer therapies (except somatostatin analogues,
   which may be allowed)

   - Must not have poorly controlled diabetes mellitus, known central nervous system
   involvement by malignant disease or insufficient bone marrow, renal, or hepatic


biological: XmAb18087

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Susan Segar

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