A Study to Evaluate the Effect of GRF6021 on Postoperative Recovery Following Primary Hip or Knee Arthroplasty

Inclusion Criteria:

* Men and women 50-85 years of age scheduled to undergo primary total hip or knee replacement surgery.
* Estimated glomerular filtration rate ≥ 45 mL/min/1.73 m2 .

Exclusion Criteria:

* Blood coagulation disorders.
* Participants who started chronic anticoagulant therapy (warfarin, heparin, low-molecular weight heparin, or Factor Xa inhibitors) in the last 6 months
* Hypercoagulable state.
* Prior hypersensitivity to any human blood product including plasma.
* Treatment with any human blood product, including transfusions and IV immunoglobulin, during the 6 months prior to screening.
* History of immunoglobulin A or haptoglobin deficiency.
* Major surgery, trauma or injury in the last 3 months or minor surgery in the last 1 month.
* Heart disease or congestive heart failure in the 6 months prior to dosing.
* Poorly controlled hypertension.
* Severe anemia.
* Functional impairment of major joint or lower extremity other than joint undergoing surgery.