Atrasentan in Patients With IgA Nephropathy

Inclusion Criteria:

Double-Blind period:

   - Biopsy-proven IgA nephropathy.

   - Receiving a maximally tolerated dose of RAS inhibitor therapy (ACEi or ARB) that has
   been stable for at least 12 weeks. Exceptions from this requirement will be made for
   subjects who are unable to tolerate RAS inhibitor therapy.

   - Total urine protein ≥1 g/day as measured via 24-hour urine collection by central
   laboratory at Screening.

   - eGFR of at least 30 mL/min/1.73 m^2 at Screening based on the CKD-EPI equation.

   - Willing and able to provide informed consent and comply with all study requirements.

   - SGLT2i Stable Stratum Only - Receiving a stable dose of an SGLT2i (per Investigator
   choice) in addition to a maximally tolerated and optimized dose of a RAS inhibitor
   that has been stable for at least 12 weeks prior to Screening.

   - All fertile men and WOCBP who engage in heterosexual intercourse must be willing to
   abide with highly effective forms of contraception, as specified in the protocol,
   throughout the study and for 1 month afterward. In WOCBP, use of contraceptive agents
   must have been started at least 1 month prior to Baseline.

Open-Label Period:

   - Willing and able to provide informed consent and comply with all OL extension study
   visits and study procedures.

   - Completed treatment through Week 132 and completed the Week 136 visit.

   - All fertile men and WOCBP who engage in heterosexual intercourse must be willing to
   abide with highly effective forms of contraception, as specified in the protocol,
   throughout the study and for 1 month afterward. In WOCBP, use of contraceptive agents
   must have been continued after completing the double-blind portion of the study.

Exclusion Criteria:

Double-blind period:

   - Concurrent diagnosis of another cause of chronic kidney disease including diabetic
   kidney disease or another primary glomerulopathy.

   - Clinical diagnosis of nephrotic syndrome.

   - BNP value of > 200 pg/mL at Screening.

   - Platelet count <80,000 per μL at Screening.

   - History of organ transplantation (subjects with history of corneal transplant are not
   excluded).

   - Use of systemic immunosuppressant medications.

   - Hemoglobin below 9 g/dL at Screening or prior history of blood transfusion for anemia
   within 3 months of Screening.

Open-label period:

   - eGFR < 25 mL/min/1.73m^2 or evidence of rapidly decreasing eGFR, including unrecovered
   acute kidney injury or expected to require renal replacement therapy within 3 months

   - BNP value of > 200 pg/mL at OL Screening.

   - Platelet count < 80,000 per μL at OL Screening.

   - Hemoglobin below 9 g/dL at OL screening or prior history of blood transfusion for
   anemia within 3 months of OL Screening.