Avexitide Safety and Efficacy to Treat Acquired Hyperinsulinemic Hypoglycemia


I'm Interested

Trial ID: NCT04652479


The primary goal of this study is to evaluate the safety and efficacy of two different dosing regimens of an investigational drug called Avexitide in treating low blood sugar in patients with Acquired Hyperinsulinemic Hypoglycemia.

Official Title

A Phase 2, Open-Label, Cross-over Study to Assess the Safety and Efficacy of Avexitide in Acquired Hyperinsulinemic Hypoglycemia

Stanford Investigator(s)

Marilyn Tan
Marilyn Tan

Clinical Associate Professor, Medicine - Endocrinology, Gerontology, & Metabolism


Inclusion Criteria:

   - History of bariatric or upper-gastrointestinal surgery (RYGB, VSG, gastrectomy,
   esophagectomy, or Nissen fundoplication) at least 12 months prior to the start of

   - History of recurrent hypoglycemia occurring after bariatric or upper-GI surgery, as
   documented in the medical record.

   - Body mass index (BMI) of up to 40 kg/m2

   - If female, must not be breastfeeding and must have a negative urine pregnancy test

Exclusion Criteria:

   - Major surgery within 6 months before randomization.

   - History of or current hyperinsulinism other than Acquired Hyperinsulinism (e.g.,
   insulin autoimmune hypoglycemia).

   - Use of agents that may interfere with glucose metabolism


drug: Avexitide


I'm Interested

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Termeh Shamloo