A Study of Teclistamab in Combination With Daratumumab Subcutaneously (SC) (Tec-Dara) Versus Daratumumab SC, Pomalidomide, and Dexamethasone (DPd) or Daratumumab SC, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma

Not Recruiting

Trial ID: NCT05083169

Purpose

The purpose of this study is to compare the efficacy of teclistamab daratumumab (Tec-Dara) with daratumumab subcutaneously (SC) in combination with pomalidomide and dexamethasone (DPd) or daratumumab SC in combination with bortezomib and dexamethasone (DVd).

Official Title

A Phase 3 Randomized Study Comparing Teclistamab in Combination With Daratumumab SC (Tec-Dara) Versus Daratumumab SC, Pomalidomide, and Dexamethasone (DPd) or Daratumumab SC, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma

Stanford Investigator(s)

Surbhi Sidana, MD
Surbhi Sidana, MD

Assistant Professor of Medicine (Blood and Marrow Transplantation and Cellular Therapy)

Eligibility


Inclusion Criteria:

   - Documented multiple myeloma as defined by the criteria: a. multiple myeloma diagnosis
   according to the International Myeloma Working Group (IMWG) diagnostic criteria, b.
   measurable disease at screening as defined by any of the following: 1) serum M-protein
   level greater than or equal to (>=) 0.5 gram per deciliter (g/dL); or 2) urine
   M-protein level >=200 milligrams (mg)/24 hours; or 3) serum immunoglobulin free light
   chain >=10 mg/dL and abnormal serum immunoglobulin kappa lambda free light chain ratio

   - Received 1 to 3 prior line(s) of antimyeloma therapy including a proteasome inhibitor
   (PI) and lenalidomide; a. participants who have received only 1 line of prior line of
   antimyeloma therapy must be lenalidomide refractory. Stable disease or progression on
   or within 60 days of the last dose of lenalidomide given as maintenance will meet this
   criterion

   - Documented evidence of progressive disease based on investigator's determination of
   response by IMWG criteria on or after their last regimen

   - Have an eastern cooperative oncology group (ECOG) performance status score of 0, 1, or
   2 at screening and prior to the start of administration of study treatment

   - Have clinical laboratory values within the specified range

Exclusion Criteria:

   - Contraindications or life-threatening allergies, hypersensitivity, or intolerance to
   any study drug or its excipients. Additional exclusion criteria pertaining to specific
   study drugs include:

      1. A participant is not eligible to receive daratumumab subcutaneous (SC) in
      combination with pomalidomide and dexamethasone (DPd) as control therapy if any
      of the following are present: 1) Contraindications or life-threatening allergies,
      hypersensitivity, or intolerance to pomalidomide, 2) Disease that is considered
      refractory to pomalidomide per IMWG,

      2. A participant is not eligible to receive daratumumab SC in combination with
      bortezomib and dexamethasone (DVd) as control therapy if any of the following are
      present: 1) Contraindications or life-threatening allergies, hypersensitivity, or
      intolerance to bortezomib, 2) Grade 1 peripheral neuropathy with pain or Grade >=
      2 peripheral neuropathy as defined by National Cancer Institute Common
      Terminology Criteria for Adverse Events (NCI-CTCAE) Version 5.0, 3) Disease that
      is considered refractory to bortezomib per IMWG, 4) Received a strong cytochromes
      P450 (CYP3A4) inducer within 5 half-lives prior to randomization

   - Received any prior B cell maturation antigen (BCMA)-directed therapy

   - Has disease that is considered refractory to an anti-cluster of differentiation 38
   (CD38) monoclonal antibody per IMWG

   - Received a cumulative dose of corticosteroids equivalent to >=140 mg of prednisone
   within 14 days before randomization

   - Received a live, attenuated vaccine within 4 weeks before randomization

   - Plasma cell leukemia at the time of screening, Waldenström's macroglobulinemia, POEMS
   syndrome (polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes),
   or primary amyloid light chain amyloidosis

Intervention(s):

drug: Daratumumab

drug: Pomalidomide

drug: Dexamethasone

drug: Bortezomib

drug: Teclistamab

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Valerie Musgrave
650-725-1647

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