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A Study of Teclistamab in Combination With Daratumumab Subcutaneously (SC) (Tec-Dara) Versus Daratumumab SC, Pomalidomide, and Dexamethasone (DPd) or Daratumumab SC, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma
Not Recruiting
Trial ID: NCT05083169
Purpose
The purpose of this study is to compare the efficacy of teclistamab daratumumab (Tec-Dara)
with daratumumab subcutaneously (SC) in combination with pomalidomide and dexamethasone (DPd)
or daratumumab SC in combination with bortezomib and dexamethasone (DVd).
Official Title
A Phase 3 Randomized Study Comparing Teclistamab in Combination With Daratumumab SC (Tec-Dara) Versus Daratumumab SC, Pomalidomide, and Dexamethasone (DPd) or Daratumumab SC, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma
Stanford Investigator(s)
Surbhi Sidana, MD
Assistant Professor of Medicine (Blood and Marrow Transplantation and Cellular Therapy)
Eligibility
Inclusion Criteria:
- Documented multiple myeloma as defined by the criteria: a. multiple myeloma diagnosis
according to the International Myeloma Working Group (IMWG) diagnostic criteria, b.
measurable disease at screening as defined by any of the following: 1) serum M-protein
level greater than or equal to (>=) 0.5 gram per deciliter (g/dL); or 2) urine
M-protein level >=200 milligrams (mg)/24 hours; or 3) serum immunoglobulin free light
chain >=10 mg/dL and abnormal serum immunoglobulin kappa lambda free light chain ratio
- Received 1 to 3 prior line(s) of antimyeloma therapy including a proteasome inhibitor
(PI) and lenalidomide; a. participants who have received only 1 line of prior line of
antimyeloma therapy must be lenalidomide refractory. Stable disease or progression on
or within 60 days of the last dose of lenalidomide given as maintenance will meet this
criterion
- Documented evidence of progressive disease based on investigator's determination of
response by IMWG criteria on or after their last regimen
- Have an eastern cooperative oncology group (ECOG) performance status score of 0, 1, or
2 at screening and prior to the start of administration of study treatment
- Have clinical laboratory values within the specified range
Exclusion Criteria:
- Contraindications or life-threatening allergies, hypersensitivity, or intolerance to
any study drug or its excipients. Additional exclusion criteria pertaining to specific
study drugs include:
1. A participant is not eligible to receive daratumumab subcutaneous (SC) in
combination with pomalidomide and dexamethasone (DPd) as control therapy if any
of the following are present: 1) Contraindications or life-threatening allergies,
hypersensitivity, or intolerance to pomalidomide, 2) Disease that is considered
refractory to pomalidomide per IMWG,
2. A participant is not eligible to receive daratumumab SC in combination with
bortezomib and dexamethasone (DVd) as control therapy if any of the following are
present: 1) Contraindications or life-threatening allergies, hypersensitivity, or
intolerance to bortezomib, 2) Grade 1 peripheral neuropathy with pain or Grade >=
2 peripheral neuropathy as defined by National Cancer Institute Common
Terminology Criteria for Adverse Events (NCI-CTCAE) Version 5.0, 3) Disease that
is considered refractory to bortezomib per IMWG, 4) Received a strong cytochromes
P450 (CYP3A4) inducer within 5 half-lives prior to randomization
- Received any prior B cell maturation antigen (BCMA)-directed therapy
- Has disease that is considered refractory to an anti-cluster of differentiation 38
(CD38) monoclonal antibody per IMWG
- Received a cumulative dose of corticosteroids equivalent to >=140 mg of prednisone
within 14 days before randomization
- Received a live, attenuated vaccine within 4 weeks before randomization
- Plasma cell leukemia at the time of screening, Waldenström's macroglobulinemia, POEMS
syndrome (polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes),
or primary amyloid light chain amyloidosis
Intervention(s):
drug: Daratumumab
drug: Pomalidomide
drug: Dexamethasone
drug: Bortezomib
drug: Teclistamab
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Valerie Musgrave
650-725-1647