A Rollover Study to Evaluate the Long-Term Safety and Efficacy of Ocrelizumab In Patients With Multiple Sclerosis


Trial ID: NCT05269004


This is a Phase IIIb, single-arm, multicenter, OLE study. Participants receiving ocrelizumab as an investigational medicinal product (IMP) in a Roche sponsored Parent study who continue to receive ocrelizumab or are in safety follow-up at the time of the closure of their respective Parent study (WA21092, WA21093 or WA25046) are eligible for enrollment in this extension study. Participants who will continue ocrelizumab treatment will receive IMP based on the dosage and administration received at the time of rollover from the Parent study.

Official Title

A Multicenter, Single-Arm, Open-Label, Extension, Rollover Study To Evaluate The Long-Term Safety And Efficacy Of Ocrelizumab In Patients With Multiple Sclerosis

Stanford Investigator(s)

Jeffrey Dunn, MD
Jeffrey Dunn, MD

Clinical Professor, Neurology & Neurological Sciences


Inclusion criteria

   - Prior eligibility for and previous participation in 1 of the Roche-sponsored Parent
   Studies WA21092, WA21093, or WA25046 with the participant either receiving ocrelizumab
   as an investigational medicinal product (IMP) or being in safety follow-up after
   treatment discontinuation

   - For female participants of childbearing potential: agreement to remain abstinent
   (refrain from heterosexual intercourse) or use adequate acceptable contraception
   during the treatment period and for at least 6 months or longer if the local label is
   more stringent after the final dose of ocrelizumab, as applicable in the ocrelizumab
   package leaflet

Exclusion criteria

   - Concurrent participation in any clinical trial (other than the Parent study)

   - Unable or unwilling to comply with the requirements of the protocol


drug: Ocrelizumab


Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305