Biomarkers for the Detection of Lymphatic Insufficiency


Trial ID: NCT02375165


Acquired lymphedema is a disease that causes chronic swelling of the limb(s). It is frequently under-recognized or misdiagnosed. This study is designed to lead to the development of an accurate, noninvasive, blood test to allow testing for lymphedema. This approach is particularly useful to investigate relative responses to treatment interventions.

Official Title

Biomarkers for the Detection of Lymphatic Insufficiency

Stanford Investigator(s)

Stanley G. Rockson, MD
Stanley G. Rockson, MD

Allan and Tina Neill Professor of Lymphatic Research and Medicine


Inclusion Criteria

For lymphedema participants:

   - clinical diagnosis of lymphedema of at least 6 months' duration

Control participants:

   - no evidence of lymphedema

Exclusion Criteria

For lymphedema participants:

   - active cancer

   - infection

   - bleeding tendency

   - active coronary artery disease

   - congestive heart failure

   - history of stroke or transient ischemic attack (TIA)

   - uncontrolled hypertension

   - renal insufficiency (serum creatinine > 1.1)

   - active inflammatory or autoimmune disease (other than lymphedema)

For control participants:

   - lymph node dissection

   - radiation therapy

   - active inflammatory disease


procedure: phlebotomy


Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305