Biospecimen Analysis in Determining Effects of Chemotherapy on Fertility in Osteosarcoma Survivors

Not Recruiting

Trial ID: NCT03206450


This research trial studies saliva, semen, and blood samples to determine effects of chemotherapy on fertility in osteosarcoma survivors. Study biospecimen samples from osteosarcoma survivors in the laboratory may help doctors learn whether chemotherapy causes fertility problems and to learn more about the long term effects.

Official Title

Effects of Modern Chemotherapy Regimens on Spermatogenesis and Steroidogenesis in Adolescent and Young Adult (AYA) Survivors of Osteosarcoma

Stanford Investigator(s)


Inclusion Criteria:

   - Received upfront therapies for osteosarcoma, which included cisplatin, (with or
   without other agents)

   - Patient must have completed cancer treatment >= 2 years prior to study enrollment

   - Osteosarcoma survivors without a systemically treated relapse or subsequent malignancy

      - Note: History of relapse or second malignancy is permitted if treated with local
      therapy only (e.g. surgery, radiation)

   - Able to speak, read and write in English, French or Spanish

   - All patients and/or their parents or legal guardians must sign a written informed

   - All institutional, Food and Drug Administration (FDA), and National Cancer Institute
   (NCI) requirements for human studies must be met


procedure: Biospecimen Collection

other: Laboratory Biomarker Analysis

other: Questionnaire Administration

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Nancy Sweeters

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