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Recruiting
I'm InterestedTrial ID: NCT04043403
Bilateral Closed Loop Deep Brain Stimulation for Freezing of Gait Using Neural and Kinematic Feedback
John E. Cahill Family Professor, Professor of Neurology and, by courtesy, of Neurosurgery
Inclusion Criteria:
- Clinically-established PD
- Meets criteria for STN DBS eligibility as part of patient's standard medical care
- The presence of complications of medication such as wearing off signs, fluctuating
responses and/or dyskinesias, and/or medication refractory tremor, and/or impairment
in the quality of life on or off medication due to these factors.
- Ability and willingness to return for study visits, at the initial programming and
after three, six and twelve months of DBS.
- Age > 25
- Freezing of gait questionnaire (FOG-Q) score ≥ 1 and/or gait sub-score (Item 3.10) of
MDS- UPDRS III ≥ 1
Exclusion Criteria:
- Dementia
- Untreated psychiatric disease
- Hoehn and Yahr stage 5 on or off medication (non-ambulatory)
- Age > 80
- Major surgical morbidities such as severe hypertension, coagulopathy and certain
metabolic conditions that might increase the risk of hemorrhage or other surgical
complications
- Presence of a cardiac pacemaker/defibrillator
- Inability to understand/sign consent
- Requires rTMS, ECT, MRI, or diathermy
- Are pregnant or lactating
- Has a cranial metallic implant
- History of seizures or epilepsy
device: Open Loop DBS (Summit RC+S)
device: Adaptive (Closed Loop) DBS (Summit RC+S)
device: Intermittent Open Loop DBS (Summit RC+S)
Recruiting
I'm Interested
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Sudeep Aditham
650-723-6709