Cyclosporine in Treating Patients With Recurrent or Refractory Angioimmunoblastic T-Cell Lymphoma

Not Recruiting

Trial ID: NCT00070291


RATIONALE: Cyclosporine may help the immune system slow the growth of angioimmunoblastic T-cell lymphoma. PURPOSE: This phase II trial is studying how well cyclosporine works in treating patients with recurrent or refractory angioimmunoblastic T-cell lymphoma.

Official Title

A Phase II Study of Cyclosporine in the Treatment of Angioimmunoblastic T-Cell Lymphoma

Stanford Investigator(s)

Harlan Pinto
Harlan Pinto

Associate Professor of Medicine (Oncology) and of Otolaryngology - Head & Neck Surgery


Inclusion Criteria:

   - Diagnosis of angioimmunoblastic T-cell lymphoma (recurrent or refractory) based on
   histologic examination.

   - At least one objective measurable or evaluable disease parameter.

   - Have failed at least one type of treatment: chemotherapy, auto-transplant, or steroid
   treatment. Patients may not receive concurrent chemotherapy.

   - Eastern Cooperative Oncology Group (ECOG) performance status of 0-2.

   - Adequate renal function as indicated by creatinine <= 1.5 the upper limit of normal

   - Adequate liver function as indicated by alkaline phosphatase, Aspartate
   Aminotransferase (AST), and Alanine Aminotransferase (ALT) <= 2x the upper limit of

   - Total bilirubin <= 2x the upper limit of normal.

   - Age 18 or older.

Exclusion Criteria:

   - Prior cyclosporine or Tacrolimus (FK506).

   - Prior allogeneic transplant.

   - Evidence of active infection.

   - Congestive heart failure, kidney failure, liver failure, or other severe

   - Evidence of active neurological impairment.

   - Previous history of hypersensitivity to cyclosporine and/or Cremorphor EL
   (polyoxyethylated oil).

   - History of other malignancies (other than cured carcinomas in situ of the cervix or
   basal cell carcinoma of the skin).

   - pregnant or breastfeeding women.

   - Human immunodeficiency virus (HIV) positive.


drug: cyclosporine

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Cancer Clinical Trials Office

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