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Recruiting
I'm InterestedTrial ID: NCT00784134
Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III
Clinical Associate Professor, Neurology & Neurological Sciences
Clinical Professor, Neurology & Neurological Sciences Clinical Professor (By courtesy), Neurosurgery
Coyote Foundation Professor and Professor, by courtesy, of Neurosurgery
Professor of Neurology and, by courtesy, of Neurosurgery
Professor of Neurology and of Neurosurgery
Clinical Professor, Neurology & Neurological Sciences Clinical Professor (By courtesy), Neurosurgery
Inclusion Criteria:
- Age 18-80
- Symptom onset less than 24 hrs prior to diagnostic CT scan
- Spontaneous ICH less than or equal to 30 cc or primary IVH
- IVH obstructing 3rd and/or 4th ventricles
- ICH clot stability at 6 hours or more post IVC placement
- IVH clot stability at 6 hours or more post IVC placement
- Catheter tract bleeding stability 6 hours or more post IVC placement
- EVD placed per standard medical care
- SBP less than 200 mmHg sustained for 6 hours prior to drug administration
- Able to randomize within 72 hours of diagnostic CT scan
- Historical Rankin of 0 or 1
Exclusion Criteria:
- Suspected or untreated ruptured cerebral aneurysm, AVM, or tumor
- Presence of a choroid plexus vascular malformation or Moyamoya
- Clotting disorders
- Platelet count less than 100,000, INR greater than 1.4
- Pregnancy
- Infratentorial hemorrhage
- SAH at clinical presentation
- ICH/IVH enlargement that cannot be stabilized in the treatment time window
- Ongoing internal bleeding
- Superficial or surface bleeding
- Prior enrollment in the study
- Any other condition that the investigator believes would pose a significant hazard to
the subject if the investigational therapy were initiated
- Planned or simultaneous participation (between screening and Day-30) in another
interventional medical investigation or clinical trial.
- No subject or legal representative to give written informed consent
other: Normal saline
drug: Alteplase
Recruiting
I'm Interested
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Christine Wijman
6507234448