Cerebral Function Monitoring in Premature Infants

Not Recruiting

Trial ID: NCT00873847

Purpose

This observational study tests the feasibility of enrolling subjects and obtaining an amplitude-integrated electroencephalogram (aEEG) within the first 72 hours of life, a second aEEG recording between 72-168 hours of life, and weekly thereafter up to 36 weeks post-menstrual age. It will enroll 85-100 infants between 401-1,000 grams birth weight OR between 23 0/7 and 28 6/7 weeks gestational age born at the 7 participating NICHD Neonatal Research Network sites.

Official Title

Cerebral Function Monitoring and Brain Injury in Preterm Infants: Correlation With Neuroimaging Abnormalities and Neurodevelopmental Impairment - a Pilot Study

Stanford Investigator(s)

Eligibility

Inclusion Criteria:

* Inborn infants
* Between 401 grams and 1,000 grams inclusive birth weight OR between 23 0/7 and 28 6/7 weeks inclusive gestational age
* Decision to provide full intensive care support
* Less than 72 hours of age

Exclusion Criteria:

* Non-intact skin at the central or parietal regions of scalp
* Presence of known or suspected congenital anomalies, including:
* Congenital central nervous system malformations
* Chromosomal anomalies or multiple congenital anomalies
* Complex congenital heart disease
* Inborn error of metabolism
* Acidosis (pH \< 6.8 for \> 2 hours)
* Persistent bradycardia \[HR \< 100 bpm\] associated with hypoxia for \> 2 hours

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305