Cerebral Function Monitoring in Premature Infants

Not Recruiting

Trial ID: NCT00873847

Age - N/A-72 Hours Gender - All Accepting Healthy Volunteers - No

Purpose

This observational study tests the feasibility of enrolling subjects and obtaining an amplitude-integrated electroencephalogram (aEEG) within the first 72 hours of life, a second aEEG recording between 72-168 hours of life, and weekly thereafter up to 36 weeks post-menstrual age. It will enroll 85-100 infants between 401-1,000 grams birth weight OR between 23 0/7 and 28 6/7 weeks gestational age born at the 7 participating NICHD Neonatal Research Network sites.

Official Title

Cerebral Function Monitoring and Brain Injury in Preterm Infants: Correlation With Neuroimaging Abnormalities and Neurodevelopmental Impairment - a Pilot Study

Stanford Investigator(s)

Alexis Davis

Eligibility


Inclusion Criteria:

   - Inborn infants

   - Between 401 grams and 1,000 grams inclusive birth weight OR between 23 0/7 and 28 6/7
   weeks inclusive gestational age

   - Decision to provide full intensive care support

   - Less than 72 hours of age

Exclusion Criteria:

   - Non-intact skin at the central or parietal regions of scalp

   - Presence of known or suspected congenital anomalies, including:

   - Congenital central nervous system malformations

   - Chromosomal anomalies or multiple congenital anomalies

   - Complex congenital heart disease

   - Inborn error of metabolism

   - Acidosis (pH < 6.8 for > 2 hours)

   - Persistent bradycardia [HR < 100 bpm] associated with hypoxia for > 2 hours

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Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305

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