Controlled Ventilation CT in CF Infants

Not Recruiting

Trial ID: NCT01200888


The objective of the study is to implement a new method of performing chest CT imaging in young children with cystic fibrosis at Packard Children's Hospital. This technique will be used to evaluate early lung disease comparing quantitative chest CT air trapping and airway measurements with lung function measurements in infants, toddlers, and young children with chronic lung disease.

Official Title

Differentiating Outcome Measures in Infants/Young Children With Cystic Fibrosis Utilizing Controlled Ventilation Infant/Young Child Chest CT Scanning and Lung Function Testing

Stanford Investigator(s)

Beverley Newman

Professor of Radiology (Pediatric Radiology)


Inclusion Criteria:

   1. Infants and young children (age ~ 2/3 months to < 5 years)

   2. Diagnosed with cystic fibrosis with either 2 identified CFTR gene mutations, or a
   positive sweat chloride

   3. Informed consent by parent or legal guardian.

   4. Ability to comply with study visit procedures as judged by the investigator.

Exclusion Criteria:

   1. Acute wheezing and/or respiratory distress at either study visit.

   2. Acute intercurrent respiratory infection, defined as an increase in cough, wheezing,
   or respiratory rate with onset in 1 week preceding Study visit.

   3. Oxygen saturation < 90% on room air at study visit.

   4. Any medical condition that in the opinion of the investigator precludes subject

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Colleen Dunn