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Computed Tomography Perfusion (CTP) to Predict Response to Recanalization in Ischemic Stroke Project (CRISP)
Not Recruiting
Trial ID: NCT01622517
Purpose
The overall goal of the CTP to predict Response to recanalization in Ischemic Stroke Project
(CRISP) is to develop a practical tool to identify acute stroke patients who are likely to
benefit from endovascular therapy.
The project has two main parts. During the first part, the investigators propose to develop a
fully automated system (RAPID) for processing of CT Perfusion (CTP) images that will generate
brain maps of the ischemic core and penumbra. There will be no patient enrollment in part one
of this project.
During the second part, the investigators aim to demonstrate that physicians in the emergency
setting, with the aid of a fully automated CTP analysis program (RAPID), can accurately
predict response to recanalization in stroke patients undergoing revascularization. To
achieve this aim the investigators will conduct a prospective cohort study of 240 consecutive
stroke patients who will undergo a CTP scan prior to endovascular therapy. The study will be
conducted at four sites (Stanford University, St Luke's Hospital, University of Pittsburgh
Medical Center, and Emory University/Grady Hospital). Patients will have an early follow-up
MRI scan within 12+/-6 hours to assess reperfusion and a late follow-up MRI scan at day 5 to
determine the final infarct.
Official Title
Computed Tomography Perfusion (CTP) to Predict Response to Recanalization in Ischemic Stroke Project
Stanford Investigator(s)
Maarten Lansberg, MD, PhD
Professor of Neurology (Adult Neurology) and, by courtesy, of Neurosurgery
Anna Finley Caulfield, MD
Clinical Professor, Neurology & Neurological Sciences
Marion S. Buckwalter, MD, PhD
Professor of Neurology (Adult Neurology) and of Neurosurgery
Chitra Venkatasubramanian, MBBS, MD, MSc, FNCS
Clinical Professor, Neurology & Neurological Sciences Clinical Professor (By courtesy), Neurosurgery
Neil Schwartz, MD, PhD
Clinical Professor, Neurology & Neurological Sciences Clinical Professor (By courtesy), Neurosurgery
Greg Zaharchuk
Professor of Radiology (Neuroimaging and Neurointervention)
Gregory W. Albers, MD
Coyote Foundation Professor and Professor, by courtesy, of Neurosurgery
Huy M. Do, MD
Professor of Radiology (Neuroimaging and Neurointervention) and, by courtesy, of Neurosurgery and of Otolaryngology - Head & Neck Surgery (OHNS)
Eligibility
Inclusion Criteria:
1. be 18 or older;
2. have a clinical diagnosis of ischemic stroke and a score of 5 or more points on the
NIHSSS;
3. be scheduled to undergo intraarterial (IA) therapy for acute hemispheric stroke
(either as primary therapy or as adjuvant therapy following intravenous tPA
treatment);
4. be scheduled to have a standard CT including perfusion imaging and CT angiography of
the circle of Willis (CTA) prior to IA therapy;
5. begin intra-arterial thrombectomy within 90 minutes of completion of the CT scan and
within 18 hours of symptom onset. (Start of IA therapy is defined as the time of
insertion of the femoral artery sheath; Time of brain scan is defined as the time that
the scan is completed); and
6. have provided informed consent.
Exclusion Criteria:
1. have any pre-existing illness resulting in a modified Rankin Scale Score of 3 or
higher prior to the qualifying stroke;
2. are pregnant.
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Stephanie M Kemp, BS
650-723-4481