Composite Health Assessment Risk Model (CHARM) for Older Adults (BMT CTN 1704)

Not Recruiting

Trial ID: NCT03992352


Prospective observational multicenter study of allogeneic Hematopoietic Stem Cell Transplantation (HCT) in recipients 60 years and older to assess important determinants of health status to be combined into a composite health risk model to improve risk assessment of non-relapse mortality (NRM).

Official Title

Composite Health Assessment Risk Model (CHARM) for Older Adults: Applying Pre-Transplant Comorbidity, Geriatric Assessment, and BioMarkers on Non-Relapse Mortality After Allogeneic Transplant (BMT CTN 1704)

Stanford Investigator(s)

Laura Johnston
Laura Johnston

Professor of Medicine (Blood and Marrow Transplantation and Cellular Therapy)


Inclusion Criteria:

   1. Subject is > 60.0 years old at time of enrollment.

   2. Hematological malignancy as an indication for allogeneic transplantation.

   3. Eligible for allogeneic transplantation based on institutional standards

   4. First allogeneic transplant planned. Any conditioning regimen and allogeneic donor is

   5. Able to speak and read English. Spanish, and Mandarin will be acceptable when sites
   have ability to perform healthcare provider tests in those languages.

   6. Written informed consent

Exclusion Criteria:

1. Prior allogeneic HCT


diagnostic test: Age 60+ with planned HCT for Hematologic Malignancy

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Melanie Gaudinez

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