Comparative Effectiveness of Online 8-session CBT vs. 1-Session Empowered Relief for Chronic Pain - The PROGRESS Study


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Trial ID: NCT05612750


The purpose of this study is to conduct a pragmatic clinical trial comparing the effectiveness of: (1) 8-week cognitive behavioral therapy for chronic pain (pain-CBT; sixteen hours total treatment time); and (2) a 1-session pain relief skills intervention for chronic pain (Empowered Relief; two hours total treatment time).

Official Title

Comparative Effectiveness of Online Cognitive Behavioral Therapy vs. An Online Single-Session Pain Relief Skills Class for Chronic Pain - The PROGRESS Study

Stanford Investigator(s)

Beth Darnall
Beth Darnall

Professor of Anesthesiology, Perioperative and Pain Medicine (Adult Pain) and, by courtesy, of Psychiatry and Behavioral Sciences (General Psychiatry & Psychology (Adult))


Inclusion Criteria:

   1. At least 18 years of age or older of either sex (and all genders).

   2. Chronic pain (pain that occurs on at least half of the days of 3 months or more).

   3. Past-month average pain intensity score of at least 3/10.

   4. Ability to adhere to and complete study protocols.

Exclusion Criteria:

   1. Inability to provide informed consent.

   2. Cognitive impairment, non-English speaking, or psychological factors that would
   preclude comprehension of material and/or full participation in the study including
   group treatment.

   3. Active suicidality at screening.

   4. Study staff may exclude individuals with a known history of disruptive behavior to
   minimize contamination of the learning environment for an entire treatment cohort.

   5. Receipt of either study treatment in the past 3 months.


behavioral: Education


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Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Emma A Adair, BS