Duloxetine for the Treatment of Dysthymia

Not Recruiting

Trial ID: NCT00185575

Purpose

The purpose of this study is to test the hypothesis that duloxetine (Cymbalta), in doses of 60 or 120 mg/day, is an effective and tolerable treatment for adult outpatients suffering from dysthymia. Dysthymia is chronic, mild depression characterized by feeling sad or low more days than not for more than 2 years.

Official Title

Duloxetine for the Treatment of Dysthymia

Stanford Investigator(s)

Elias Aboujaoude, MD, MA

Clinical Professor, Psychiatry and Behavioral Sciences

Eligibility

Inclusion Criteria::

* Sign an informed consent form
* 18 years of age or older
* Females not pregnant or breastfeeding or planning pregnancy and using an acceptable form of contraception
* Meet DSM-IV criteria for dysthymia
* A screening IDS-C score of 17 or greater
* No history of serious or unstable medical disorder
* Not taking any significant concurrent medications
* Not currently receiving psychotherapy Exclusion Criteria:- Suffering from DSM-IV defined
* delirium, dementia, amnestic, or other cognitive disorders
* mental disorders due to a general medical condition
* factitious or somatoform disorders
* mental retardation or developmental disabilities
* substance or alcohol abuse within the last 3 months
* depressive disorders with current suicidal risk
* psychotic disorders including delusional disorder, somatic type
* dissociative disorder
* personality disorders sufficiently severe to interfere with study participation
* History of DSM-IV defined bipolar I or II disorder
* History of non-response of dysthymia to adequate antidepressant medication
* History of major depression refractory to two adequate trials of antidepressants

Intervention(s):

drug: duloxetine

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Nona Gamel
6507255180