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DCM Precision Medicine Study
Trial ID: NCT03037632
The aims of the DCM Precision Medicine Study are to test the hypothesis that DCM has substantial genetic basis and to evaluate the effectiveness of a family communication intervention in improving the uptake and impact of family member clinical screening.
Precision Medicine for Dilated Cardiomyopathy in European and African Ancestry
Euan A. Ashley
Associate Dean, School of Medicine, Roger and Joelle Burnell Professor of Genomics and Precision Health, Professor of Medicine (Cardiovascular Medicine), of Genetics, of Biomedical Data Science and, by courtesy, of Pathology
- Meeting criteria for dilated cardiomyopathy (DCM) :
- Left ventricular ejection fraction <50%
- Left ventricular enlargement (A left ventricular end-diastolic dimension >
95%tile population standard based on gender and height).
- Detectable causes of cardiomyopathy, except genetic, excluded beyond a reasonable
doubt at the time of DCM diagnosis (that is, meeting clinical criteria for idiopathic
- Any age (including children)
- Non-Hispanic and Hispanic ethnicity
- All races (PI pre-approval required for recruitment beyond pre-specified recruitment
- Ability to give informed consent
- Ability to communicate in English (except Spanish language at sites approved to
recruit individuals of Hispanic ethnicity)
- Willingness to participate in a family-based study (patient willing to work with a
clinical site and/or OSU to facilitate the recruitment and enrollment of family
members to the study).
- Coronary artery disease (CAD) causing ischemic cardiomyopathy (> 50% narrowing, any
major epicardial coronary artery)
- Primary valvular disease
- Adriamycin or other cardiotoxic drug exposure
- Other forms of cardiomyopathy: Hypertrophic, Restrictive, or Arrhythmogenic Right
- Congenital heart disease
- Other detectable causes of dilated cardiomyopathy, including sarcoid and
- Other active multi-system disease that may cause DCM (e.g., active connective tissue
- Severe and untreated or untreatable hypertension (systolic blood pressures routinely
greater than 180 mm Hg and/or diastolic blood pressures greater than 120 mm Hg, and if
resistant to multidrug treatment).
- However, conventional risk factors for DCM, including obesity, routinely treated
hypertension, alcohol use, pregnancy or the peri-partum period, or left ventricular
noncompaction, will NOT be considered exclusion criteria.
behavioral: Family Heart Talk Booklet
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