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Not Recruiting
Trial ID: NCT01007071
Effects of Growth Hormone on Cognition and Cerebral Metabolism in Adults
Clinical Professor, Psychiatry and Behavioral Sciences
Inclusion Criteria:
- Ability to provide written informed consent and comply with study assessments for the
full duration of the study
- Age 18-65 years old
- Both men and women
- Naive to GH replacement therapy
- Diagnosis of Growth Hormone deficiency, adult onset
- Good general health
- Normal thyroid, adrenal or gonadal function, or stable thyroid, glucocorticoid (at
replacement doses) and gonadal replacement therapy for at least 3 months prior to
study initiation. If subjects are receiving transdermal testosterone, attainment of
mid-normal serum values will be considered adequate. If subjects are on intramuscular
testosterone, attainment of mid-normal serum testosterone at mid-injection cycle will
be considered adequate
Exclusion Criteria:
- Pregnancy (positive pregnancy test) prior to enrollment in the study
- Any other condition that the investigator believes would pose a significant hazard to
the subject if Growth Hormone therapy was initiated
- Idiopathic Growth Hormone Deficiency
- DSM IV diagnosis of Major Depressive Disorder with or without psychotic features,
Bipolar II Disorder with or without psychotic features in a major depressive episode
- Current use of psychotropic medications
- History of moderate to severe brain injury
- Clinically significant cardiovascular disease
- Anemia with hct<30
- Renal insufficiency with creatinine >2.0
- Recent history of excessive alcohol use
- Participation in another simultaneous medical investigation or trial
- Active neoplasm
- Prader Willi Syndrome
- History of brain radiation
- Chemotherapy, past or present use
- History of head or eye injury involving persistent metal fragments, and implanted
electrical device (such as a heart pacemaker)
drug: Human Growth Hormone (1-134)
drug: Placebo
Not Recruiting
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Laurence Katznelson, MD
650-721-1020