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Effects of Deep Brain Stimulation (DBS) Frequency on Neural Synchrony
Trial ID: NCT02304848
The purpose of this study is to evaluate the effects of low frequency deep brain stimulation on subthalamic nucleus neural synchrony. Low frequency stimulation does not improve the cardinal motor signs of Parkinson's disease, and may be beneficial only for gait and speech. This study will provide insight into what the effects of low frequency stimulation are on neural synchrony.
- A diagnosis of idiopathic Parkinson's disease, with bilateral symptoms at Hoehn and
Yahr Stage greater than or equal to II.
- Documented improvement in motor signs on versus off dopaminergic medication, with a
change in the Unified Parkinson's Disease Rating Scale motor (UPDRS III) score of >=
30% off to on medication.
- The presence of complications of medication such as wearing off signs, fluctuating
responses and/or dyskinesias, and/or medication refractory tremor, and/or impairment
in the quality of life on or off medication due to these factors.
- Subjects should be on stable doses of medications, which should remain unchanged until
the DBS system is activated. After the DBS system is optimized (during which time the
overall medication dose may be reduced to avoid discomfort and complications such as
dyskinesias) the medication dose should remain unchanged, if possible, for the
duration of the study.
- Treatment with carbidopa/levodopa, and with a dopamine agonist at the maximal
tolerated doses as determined by a movement disorders neurologist.
- Age > 18
- Subjects with significant cognitive impairment and/or dementia as determined by a
standardized neuropsychological battery.
- Subjects with clinically active depression, defined according to the Diagnostic and
Statistical manual of Mental Disorders, Fourth Edition (DSM-IV) criteria and as scored
on a validated depression assessment scale.
- Subjects with very advanced Parkinson's disease, Hoehn and Yahr stage 5 on medication
- Age > 80.
- Subjects with an implanted electronic device such as a neurostimulator, cardiac
pacemaker/defibrillator or medication pump.
- Subjects, who are pregnant, are capable of becoming pregnant, or who are breast
- Patients with cortical atrophy out of proportion to age or focal brain lesions that
could indicate a non-idiopathic movement disorder as determined by MRI
- Subjects having a major comorbidity increasing the risk of surgery (prior stroke,
severe hypertension, severe diabetes, or need for chronic anticoagulation other than
- Subjects having any prior intracranial surgery.
- Subjects with a history of seizures.
- Subjects, who are immunocompromised.
- Subjects with an active infection.
- Subjects, who require diathermy, electroconvulsive therapy (ECT), or transcranial
magnetic stimulation (TMS) to treat a chronic condition.
- Subjects, who have an inability to comply with study follow-up visits.
- Subjects, who are unable to understand or sign the informed consent
other: DBS (Deep Brain Stimulation)
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