Efficacy and Safety Study of Maribavir Treatment Compared to Investigator-assigned Treatment in Transplant Recipients With Cytomegalovirus (CMV) Infections That Are Refractory or Resistant to Treatment With Ganciclovir, Valganciclovir, Foscarnet, or Cidofovir

Inclusion Criteria:

   1. The participant must be able to provide written, personally signed, and dated informed
   consent to participate in the study before completing any study-related procedures. As
   applicable, a parent/both parents or legally authorized representative (LAR) must
   provide signature of informed consent and there must be documentation of assent by the
   participant before completing any study-related procedures.

   2. The participant must be a recipient of hematopoietic stem cell or solid organ
   transplant.

   3. The participant must have a documented CMV infection in whole blood or plasma, with a
   screening value of greater than or equal to (>=) 2730 international units per
   milliliter (IU/mL) in whole blood or >= 910 IU/mL in plasma in 2 consecutive
   assessments, separated by at least 1 day, as determined by local or central specialty
   laboratory quantitative polymerase chain reaction (qPCR) or comparable quantitative
   CMV DNA results. Both samples should be taken within 14 days prior to randomization
   with second sample obtained within 5 days prior to randomization. The same laboratory
   and same sample type (whole blood or plasma) must be used for these assessments.

   4. The participant must have a current CMV infection that is refractory to the most
   recently administered of the four anti-CMV treatment agents. Refractory is defined as
   documented failure to achieve greater than (>) 1 log10 (common logarithm to base 10)
   decrease in CMV DNA level in whole blood or plasma after a 14 day or longer treatment
   period with intravenous (IV) ganciclovir/oral valganciclovir, IV foscarnet, or IV
   cidofovir.

   a. Participants with documentation of 1 or more CMV genetic mutations associated with
   resistance to ganciclovir/valganciclovir, foscarnet, and/or cidofovir must also meet
   the definition of refractory CMV infection.

   5. The Investigator must be willing to treat the participant with at least one of the
   available anti-CMV drugs (ganciclovir, valganciclovir, foscarnet, or cidofovir). Note:
   Combination therapy with foscarnet and cidofovir is not permitted in the
   investigator-assigned anti-CMV treatment (IAT) arm due to the potential for serious
   nephrotoxicity.

   6. The participant must be >= 12 years of age at the time of consent.

   7. The participant must weigh >= 35 kilogram (kg).

   8. The participant must have all of the following results as part of screening laboratory
   assessments (results from either the central laboratory or a local laboratory can be
   used for qualification):

      1. Absolute neutrophil count (ANC) >= 1000/ millimeter cube (mm^3) (1.0 x 10^9/liter
      [L])

      2. Platelet count >= 25,000/mm^3 [25 x 10^9/L],

      3. Hemoglobin >= 8 grams per deciliter (g/dL).

      4. Estimated glomerular filtration rate (eGFR) > 30 (milliliters per minute (mL/min)
      /1.73 square meter (m^2) as assessed by Modification of Diet in Renal Disease
      (MDRD) formula for participants >= 18 years of age or Schwartz formula for
      participants less than (<) 18 years of age.

   9. The participant must have a negative serum beta-human chorionic gonadotropin
   (beta-HCG) pregnancy test at screening, if a female of child bearing potential.
   Additional urine pregnancy tests may be done per institutional requirements. Sexually
   active females of child bearing potential must agree to comply with any applicable
   contraceptive requirements of the protocol. If male, must agree to use an acceptable
   method of birth control, as defined in the protocol, during the study treatment
   administration period and for 90 days afterward if treated with maribavir,
   ganciclovir, valganciclovir, or cidofovir and for 180 days afterward if treated with
   foscarnet.

10. The participant must be able to swallow tablets, or receive tablets crushed and/or
   dispensed in water via nasogastric or orogastric tube.

11. The participant must be willing and have an understanding and ability to fully comply
   with study procedures and restrictions defined in the protocol.

12. The participant must be willing to provide necessary samples (example [e.g,] biopsy)
   for the diagnosis of tissue invasive CMV disease at baseline as determined by the
   Investigator.

13. The participant must have a life expectancy of >= 8 weeks.

Exclusion Criteria:

   1. Have a current CMV infection that is considered refractory or resistant due to
   inadequate adherence to prior anti-CMV treatment, to the best knowledge of the
   Investigator.

   2. Require ganciclovir, valganciclovir, foscarnet, or cidofovir administration for
   conditions other than CMV when study treatment is initiated (example: herpes simplex
   virus (HSV) coinfection requiring use of any of these agents after the randomization)
   or would need a coadministration with maribavir for CMV infection. NOTE: A participant
   who is not continuing with the same anti-CMV drug(s) (ganciclovir, valganciclovir or
   foscarnet) for the study treatment (if randomized to the investigator assigned
   anti-CMV treatment arm), must discontinue their use before the first dose of study
   drug. If participant is currently being treated with cidofovir and is assigned another
   anti-CMV therapy by the investigator, the participant must discontinue its use at
   least 14 days prior to randomization at Visit 2/Day 0 and the first dose of study
   treatment.

   3. Be receiving leflunomide, letermovir, or artesunate when study treatment is initiated.
   NOTE: Participants receiving leflunomide must discontinue the use at least 14 days
   prior to randomization at Visit 2/Day 0 and the first dose of study treatment.
   Participants receiving letermovir must discontinue use at least 3 days prior to the
   first dose of study treatment. Participants receiving artesunate must discontinue the
   use prior to the first dose of study treatment.

   4. Have severe vomiting, diarrhea, or other severe gastrointestinal illness within 24
   hours prior to the first dose of study treatment that would preclude administration of
   oral/enteral medication.

   5. Have known hypersensitivity to the active substance or to an excipient for a study
   treatment.

   6. Have tissue invasive CMV disease with central nervous system involvement including the
   retina (example, CMV retinitis).

   7. Have serum aspartate aminotransferase (AST) > 5 times upper limit of normal (ULN) at
   screening, or serum alanine aminotransferase (ALT) > 5 times ULN at screening, or
   total bilirubin >= 3.0 x ULN at screening (except for documented Gilbert's syndrome),
   by local or central lab. Participants with biopsy confirmed CMV hepatitis will not be
   excluded from study participation despite AST or ALT > 5 times ULN at screening.

   8. Have known positive results for human immunodeficiency virus (HIV). Participants must
   have a confirmed negative HIV test result within 3 months of study entry or, if
   unavailable, be tested by a local laboratory during the screening period.

   9. Require mechanical ventilation or vasopressors for hemodynamic support at the time of
   enrollment.

10. Be female and pregnant or breast feeding.

11. Have previously received maribavir.

12. Have received any investigational agent with known anti-CMV activity within 30 days
   before initiation of study treatment or investigational CMV vaccine at any time.

13. Have received any unapproved agent or device within 30 days before initiation of study
   treatment.

14. Have active malignancy with the exception of nonmelanoma skin cancer. Participants who
   have had a hematopoietic stem cell transplant (HSCT) and who experience relapse or
   progression of the malignancy as per investigator's opinion are not to be enrolled.

15. Be undergoing treatment for acute or chronic hepatitis C.

16. Have any clinically significant medical or surgical condition that, in the
   investigator's opinion, could interfere with the interpretation of study results,
   contraindicate the administration of the assigned study treatment, or compromise the
   safety or well-being of the participant.