Efficacy of Nitrous Oxide in OCD: Pilot Study


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Trial ID: NCT03826693


This study investigates whether the commonly used and well-tolerated inhaled anesthetic nitrous oxide can rapidly improve symptoms of OCD.

Official Title

Efficacy of Nitrous Oxide in OCD: Pilot Study

Stanford Investigator(s)

Peter Johannes van Roessel

Clinical Associate Professor, Psychiatry and Behavioral Sciences

Carolyn Rodriguez
Carolyn Rodriguez

Professor of Psychiatry and Behavioral Sciences (Public Mental Health and Population Sciences)


Inclusion Criteria:

* Age 18-65
* Primary diagnosis of OCD
* Sufficient severity of OCD symptoms
* Ability to tolerate a treatment-free period
* Capacity to provide informed consent

Exclusion Criteria:

* Psychiatric or medical conditions that make participation unsafe
* Pregnant or nursing females
* Concurrent use of any medications that might increase the risk of participation (e.g. drug interactions)


drug: Nitrous Oxide

drug: Nitrogen


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Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Pavithra Makunda, MS