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Functional Magnetic Resonance Imaging of Opioid Withdrawal in Healthy Human Volunteers
Trial ID: NCT01006707
Opioid medications are commonly used for pain relief. When given over time, physical dependence can occur. This results in unpleasant side effects--such as agitation and nausea--if opioid medications are suddenly stopped. However, we do not know how withdrawal affects the brain. We know that a medication named Ondansetron can help ease or prevent symptoms associated with opioid withdrawal. Through imaging of the brain by fMRI, we hope to see how opioid withdrawal, with and without the administration of ondansetron, affects brain activity.
fMRI Imaging of Opioid Withdrawal in Healthy Human Volunteers
- Patients will be healthy male volunteers, ages 18-35.
- Females were excluded due to menstrual cycle modulation of opioid response.
- We will exclude individuals with Raynaud's disease or a history of coronary artery
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