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Gastrointestinal Microbiota in Primary Sclerosing Cholangitis and Biliary Atresia With Vancomycin
Not Recruiting
Trial ID: NCT01322386
Purpose
The goals of the proposed work are two fold:
Firstly, to see if the antibiotic vancomycin may be used for the early treatment of Biliary
Atresia (BA) and Primary Sclerosing Cholangitis (PSC). The investigators hope to learn what
effect Vancomycin has on the bacteria that are present in stool, body fluid or intestinal
tissue on someone who has BA and PSC and if so by what mechanism. Secondly, the investigators
hope to learn to characterize human intestinal microbial communities (microbiome: the
collection or collectivity of microorganisms) using molecular methods, examine the mechanisms
of interaction between host and microbiome using genomic approaches, and determine how the
microbiome both preserves local health and promotes pathology. The investigators will focus
on primary sclerosing cholangitis, biliary atresia, as well as states of health. The
composition of the associated microbiome will be assessed based on ribosomal DNA and RNA
sequences, and attention will be given to richness (diversity), evenness (relative
abundance), and variation with respect to time, person, and anatomic niche. Host response at
the adjacent mucosal surface will be assessed based on genome-wide gene expression patterns.
Official Title
The Human Gastrointestinal Tract Microbiota in the Setting of Treating Primary Sclerosing Cholangitis and Biliary Atresia With Vancomycin.
Stanford Investigator(s)
Eligibility
Inclusion Criteria:
- Clinical diagnosis of biliary atresia or primary sclerosing cholangitis.
- Clinical controls who are undergoing upper endoscopy or colonoscopy and do not have
biliary atresia or primary sclerosing cholangitis.
- Subjects who have been on oral vancomycin for 1 year for biliary atresia or -
Exclusion Criteria:
- Patients that have taken antibiotics within the last 3 month will be excluded as this
will alter the original bacterial flora.
Intervention(s):
drug: Vancomycin
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305