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Heritability of Opioid Effects: A Twin Study
Not Recruiting
Trial ID: NCT00672438
Purpose
Proposed twin study will test to what degree inter-individual differences in pain sensitivity
and amount of pain relief in response to opioid therapy are inherited or alternatively, are
due to environmental factors. This knowledge is important to guide future studies trying to
explain such inter-individual differences. For example, finding that differences are largely
due to environmental factors would discourage genomic studies and emphasize epidemiological
studies.
Official Title
Heritability of Opioid Effects: A Twin Study
Stanford Investigator(s)
Martin S. Angst
Professor of Anesthesiology, Perioperative and Pain Medicine
Eligibility
Inclusion Criteria:Monozygotic or dizygotic twins ages 18-70
Exclusion Criteria:(1) Clinically relevant systemic diseases such as psychiatric,
neurological, and dermatological conditions interfering with the collection and
interpretation of study data (2) History of addiction (3) Allergy to study medication (4)
Chronic intake of medication potentially interfering with pain processing (except oral
contraceptives) (5) Intake of over-the-counter analgesics within the two days prior to
study (6) Reynaud's disease (7) Pregnancy (8) Participation in other study within last 30
days (9) Personnel with direct access to addicting drugs
Intervention(s):
drug: Alfentanil
other: Saline placebo infusion
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Martha Tingle
6507242742