Hyperpolarized Carbon C 13 Pyruvate Magnetic Resonance Spectroscopic Imaging in Detecting Lactate and Bicarbonate in Participants With Central Nervous System Tumors

Not Recruiting

Trial ID: NCT03565367

Purpose

This early phase I trial studies how well hyperpolarized carbon C 13 pyruvate magnetic resonance imaging works in detecting lactate and bicarbonate in participants with central nervous system tumors. Hyperpolarized carbon C 13 pyruvate magnetic resonance imaging may be used to measure the metabolic state of malignant brain tumors.

Official Title

A Pilot Study to Assess Lactate and Bicarbonate Detection Within Malignant Brain Tumors Using [1-13C]-Pyruvate DNP Magnetic Resonance Spectroscopy (MRS)

Stanford Investigator(s)

Reena Thomas, MD PhD
Reena Thomas, MD PhD

Clinical Associate Professor, Neurology & Neurological Sciences Clinical Associate Professor (By courtesy), Neurosurgery

Eligibility

Inclusion Criteria:

* Patients with a known diagnosis of central nervous system (CNS) malignancy, including metastases, with known enhancement on magnetic resonance (MR) who are otherwise eligible to undergo MRI
* Glomerular filtration rate (GFR) \> 30 ml/min
* No allergy to gadolinium
* Ability to understand and the willingness to sign a written informed consent document

Exclusion Criteria:

* Refusal to have an IV placed for injection
* Acute major illness (e.g., unstable angina, etc.) or other condition that makes participation unsafe, per the investigator?s judgement
* Total bilirubin \> 1.5 x upper limit of normal (ULN)
* Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) \> 2.5 x ULN
* Gamma-glutamyltransferase (GGT) \> 2.5 x ULN
* Pregnant or breast-feeding
* Cardiovascular risk, including:

* Poorly controlled hypertension, defined as either systolic \> 170 or diastolic \> 110
* Congestive heart failure
* Myocardial infarction within the past year
* QT prolongation, defined as pretreatment corrected QT interval (QTc) \> 440 msec in males or \> 460 msec in females

Intervention(s):

other: Gadolinium

drug: Hyperpolarized Carbon C 13 Pyruvate

procedure: Magnetic Resonance Imaging

procedure: Magnetic Resonance Spectroscopic Imaging

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Lewis Naya
650-725-0739

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