Imaging Study of Chronic Low Back Pain in Patients Taking Pain Medication

Not Recruiting

Trial ID: NCT00388414


Duloxetine has recently been shown to be effective in reducing the pain in chronic pain patients. Duloxetine is known to exert a central mechanism, however the precise human brain structures responsible for mediating its pain-relieving properties are not known. We will use functional magnetic resonance imaging (FMRI) to investigate the neural and functional correlates of pain.

Official Title

Functional MRI Neural Correlates of Medication Efficacy in Patients With Chronic Low Back Pain

Stanford Investigator(s)

Sean Mackey, M.D., Ph.D.
Sean Mackey, M.D., Ph.D.

Redlich Professor, Professor of Anesthesiology, Perioperative, and Pain Medicine and, by courtesy, of Neurology


Inclusion Criteria:- Males aged 18-60

   - Back Pain

   - Must be able to comply with study visit schedule and other study requirements

   - Capable of performing the experimental tasks Exclusion Criteria:- Contraindications
   for MRI examination (e.g., metallic implants such as pacemakers, surgical aneurysm
   clips, or known metal fragments embedded in the body)

   - Known hypersensitivity to duloxetine or any of the inactive ingredients

   - Uncontrolled narrow-angle glaucoma


drug: Placebo

drug: duloxetine

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Neil Chatterjee