Ipilimumab and Local Radiation Therapy in Treating Patients With Recurrent Melanoma, Non-Hodgkin Lymphoma, Colon, or Rectal Cancer

Not Recruiting

Trial ID: NCT01769222


This pilot phase I/II trial studies the side effects and best of dose ipilimumab when given together with local radiation therapy and to see how well it works in treating patients with recurrent melanoma, non-Hodgkin lymphoma, colon, or rectal cancer. Monoclonal antibodies, such as ipilimumab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Radiation therapy uses high energy x rays to kill cancer cells. Giving monoclonal antibody therapy together with radiation therapy may be an effective treatment for melanoma, non-Hodgkin lymphoma, colon, or rectal cancer

Official Title


Stanford Investigator(s)

Lauren Maeda
Lauren Maeda

Clinical Associate Professor, Medicine - Oncology

George A. Fisher Jr.
George A. Fisher Jr.

Colleen Haas Chair in the School of Medicine


Inclusion Criteria:

   - Willing and able to give written informed consent

      - Before any study procedures are performed, subjects (or their legally acceptable
      representatives) will have the details of the study described to them, and they
      will be given a written informed consent document to read; then, if subjects
      consent to participate in the study, they will indicate that consent by signing
      and dating the informed consent document in the presence of study personnel

   - Histologically confirmed malignancy

      - In Phase 1, histologically confirmed melanoma.

      - In Phase 2, histologically confirmed melanoma, non-Hodgkin lymphoma, or
      colorectal carcinoma

   - Must have failed at least one systemic therapy or be intolerant to at least one prior
   systemic treatment

   - Must have at least two lesions of evaluable size by modified World Health Organization
   (mWHO)/Cheson criteria; one of two lesions must be amenable to biopsy (core or fine
   needle aspirate) and intratumoral injection of up to 5ml (diameter >= 10mm)

   - Subjects with asymptomatic brain metastases are eligible; (systemic steroids should be
   avoided if possible, or the subject should be stable on the lowest clinically
   effective dose, as steroids as they may interfere with the activity of ipilimumab if
   administered at the time of the first ipilimumab dose)

   - Must be at least 28 days since treatment with standard or investigational
   chemotherapy, biochemotherapy, surgery, radiation, cytokine therapy, or immunotherapy,
   and recovered from any clinically significant toxicity experienced during treatment

   - Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2

   - Life expectancy of >= 16 weeks

   - Subjects must have baseline (screening/baseline) radiographic images, (e.g. brain,
   chest, abdomen, pelvis, and bone scans with specific imaging tests to be determined by
   the attending physician) within 6 weeks of initiation of ipilimumab

   - White blood cell (WBC) >= 2000/uL (~2 x 10^9/L)

   - Absolute neutrophil count (ANC) >= 1000/uL (~0.5 x 10^9/L)

   - Platelets >= 75 x 10^3/uL (~75 x 10^9/L)

   - Hemoglobin >= 9 g/dL (may be transfused)

   - Creatinine =< 2.0 x upper limit of normal (ULN)

   - Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x ULN for
   subjects without liver metastasis =< 5 times for liver metastases

   - Bilirubin =< 2.0 x ULN (except for subjects with Gilbert's syndrome, who must have a
   total bilirubin of less than 3.0 mg/dL)

   - No active or chronic infection with human immunodeficiency virus (HIV), hepatitis B,
   or hepatitis C

   - Women of childbearing potential (WOCBP) must be using an adequate method of
   contraception to avoid pregnancy throughout the study and for up to 26 weeks after the
   last dose of investigational product, in such a manner that the risk of pregnancy is
   minimized; WOCBP include any female who has experienced menarche and who has not
   undergone successful surgical sterilization (hysterectomy, bilateral tubal ligation,
   or bilateral oophorectomy) or is not post-menopausal; post-menopause is defined as:

      - Amenorrhea >= 12 consecutive months without another cause, or

      - For women with irregular menstrual periods and taking hormone replacement therapy
      (HRT), a documented serum follicle stimulating hormone (FSH) level >= 35 mIU/mL

   - Women who are using oral contraceptives, other hormonal contraceptives (vaginal
   products, skin patches, or implanted or injectable products), or mechanical products
   such as an intrauterine device or barrier methods (diaphragm, condoms, spermicides) to
   prevent pregnancy, or are practicing abstinence or where their partner is sterile (eg,
   vasectomy) should be considered to be of childbearing potential; WOCBP must have a
   negative serum or urine pregnancy test (minimum sensitivity 25 IU/L or equivalent
   units of human chorionic gonadotropin [HCG]) within 72 hours before the start of

   - Men of fathering potential must be using an adequate method of contraception to avoid
   conception throughout the study (and for up to 26 weeks after the last dose of
   investigational product) in such a manner that the risk of pregnancy is minimized

Exclusion Criteria:

   - Any other malignancy from which the patient has been disease-free for less than 5
   years, with the exception of adequately treated and cured basal or squamous cell skin
   cancer, superficial bladder cancer or carcinoma in situ of the cervix

   - Autoimmune disease: patients with a history of inflammatory bowel disease, including
   ulcerative colitis and Crohn's disease, are excluded from this study, as are patients
   with a history of symptomatic disease (eg, rheumatoid arthritis, systemic progressive
   sclerosis [scleroderma], systemic lupus erythematosus, autoimmune vasculitis [eg,
   Wegener's Granulomatosis]); motor neuropathy considered of autoimmune origin (e.g.
   Guillain-Barre Syndrome and Myasthenia Gravis)

   - Any underlying medical or psychiatric condition, which in the opinion of the
   investigator will make the administration of ipilimumab hazardous or obscure the
   interpretation of adverse events (AEs), such as a condition associated with frequent

   - Patients with underlying heart conditions who are deemed ineligible for surgery by
   cardiology consult

   - Any non-oncology vaccine therapy used for prevention of infectious diseases (for up to
   1 month before or after any dose of ipilimumab)

   - A history of prior treatment with ipilimumab or prior CD137 agonist or CTLA 4
   inhibitor or agonist

   - Concomitant therapy with any of the following: interleukin-2 (IL 2), interferon, or
   other non-study immunotherapy regimens; cytotoxic chemotherapy; immunosuppressive
   agents; other investigation therapies; or chronic use of systemic corticosteroids

      - A history of AEs with prior IL-2 or Interferon will not preclude subjects from
      entering the current study

   - Any investigational agents

   - Immunosuppressive agents (unless required for treating potential AEs)

   - Chronic systemic corticosteroids (unless required for treating treatment emergent AEs
   or required for management of signs or symptoms due to brain metastases, upon
   discussion with Bristol-Myers Squibb [BMS] medical monitor)

   - Prisoners or subjects who are compulsorily detained (involuntarily incarcerated) for
   treatment of either a psychiatric or physical (eg, infectious) illness

   - Women of childbearing potential (WOCBP) who:

      - Are unwilling or unable to use an acceptable method of contraception to avoid
      pregnancy for their entire study period and for at least 8 weeks after cessation
      of study drug, or

      - Have a positive pregnancy test at baseline, or

      - Are pregnant or breastfeeding

   - Persons of reproductive potential must agree to use an adequate method of
   contraception throughout treatment and for at least 8 weeks after ipilimumab is
   stopped; sexually active WOCBP must use an effective method of birth control during
   the course of the study, in a manner such that risk of failure is minimized; before
   study enrollment, WOCBP must be advised of the importance of avoiding pregnancy during
   study participation and the potential risk factors for an unintentional pregnancy; all
   WOCBP MUST have a negative pregnancy test before first receiving ipilimumab; if the
   pregnancy test is positive, the patient must not receive ipilimumab and must not be
   enrolled in the study


biological: ipilimumab

radiation: radiation therapy

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305

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