©2022 Stanford Medicine
iTBS in Refractory Pediatric Depression
Not Recruiting
Trial ID: NCT03845504
Purpose
This work will mark the first step in understanding the neural targets for rTMS in youth with
difficult to treat depressive symptoms, creating benchmarks for optimizing the safety and
efficacy of rTMS for pediatric populations through precision targeting, and encourage funding
applications for larger sham- controlled randomized clinical studies.
Official Title
Evaluating the Efficacy and Tolerability of Targeted Transcranial Magnetic Stimulation in Youth
Stanford Investigator(s)
Nolan Williams
Associate Professor of Psychiatry and Behavioral Sciences (Major Laboratories & Clinical Translational Neurosciences Incubator) and, by courtesy, of Radiology (Neuroimaging and Neurointervention)
Eligibility
Inclusion Criteria:
- 10 participants ages 12-21 years of age
- with at least moderate to severe depressive symptoms confirmed by the Children's
Depression Rating Scale-Revised (CDRS-R>40) or Hamilton Rating Scale for Depression
(HRSD-17 ≥ 18)
- able to commit to protocol schedule and provide Informed consent by a legal guardian
and assent by a youth participant
- have had at least one prior antidepressant treatment failure with adequate dose and
duration
Exclusion Criteria:
- prior neurological diagnosis (neurodevelopmental disorders, strokes/traumatic brain
injuries, brain tumor, epilepsy)
- contraindications for TMS or MRI e.g. have any implanted metal
- unstable medical conditions
- acute suicide risk, defined as an attempt in past 6 months that required medical
treatment, or history of ≥2 suicide attempts in the past 12 months, or has a clear cut
plan for suicide
- pregnancy, suspected pregnancy or not on birth control if sexually active; 6)
Inability to locate and quantify a motor threshold
- any factor that the PI determines to be reason for exclusion.
Intervention(s):
device: Intermittent Theta Burst Stimulation
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Romina Nejad, BS
650-497-3933