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Recruiting
I'm InterestedTrial ID: NCT01504867
LIPS-A: Lung Injury Prevention Study With Aspirin
Associate Professor of Medicine (Pulmonary and Critical Care Medicine)
Inclusion Criteria:
- Adult patients (age > 18) admitted to the hospital through the emergency department
(ED)
- At high risk of developing acute lung injury (ALI) Lung Injury Prediction Score (LIPS)
greater than or equal to 4
Exclusion Criteria:
- Anti-platelet therapy on admission or within 7 days prior to admission
- Presented to outside hospital ED > 12 hrs before arrival at site's facility
- Inability to obtain consent within 12 hours of hospital presentation
- Admitted for elective surgery
- Acute lung injury prior to randomization
- Receiving mechanical ventilation through a tracheostomy tube prior to current hospital
admission (patient who is ventilator dependent)
- Presence of bilateral pulmonary infiltrates on admission if he or she has a history of
bilateral pulmonary infiltrates (as evidenced by previous x-rays) that can reasonably
explain the current degree of pulmonary infiltrates present.
- Presentation due to pure heart failure and no other known risk factors for ALI.
- Allergy to aspirin or non steroidal anti inflammatory drugs (NSAIDs)
- Bleeding disorder
- Suspected active bleeding or judged to be at high risk for bleeding
- Active peptic ulcer disease (within past 6 months)
- Severe chronic liver disease
- Inability to administer the study drug
- Expected hospital stay < 48 hours
- Admitted for comfort or hospice care
- Patient, surrogate or physician not committed to full support. (Exception: a patient
will not be excluded if he/she would receive all supportive care except for attempts
at resuscitation from cardiac arrest)
- Not anticipated to survive > 48 hours
- Previously enrolled in this trial
- Enrolled in a concomitant intervention trial
- Pregnant or breastfeeding
drug: Aspirin
drug: Lactose powder
Recruiting
I'm Interested
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Rosemary Vojnik
650-723-7409