Long-term Cognitive, Neuropsychiatric and Functional Outcomes in Adults Who Have Received Chimeric Antigen-Receptor T-Cell (CAR-T) Therapy for Aggressive Lymphoma at Stanford

Not Recruiting

Trial ID: NCT05416554

Purpose

This study aims to assess the feasibility of performing neuropsychological testing to measure the cognitive performance of individuals following Axicabtagene ciloleucel CAR-T therapy at Stanford.

Official Title

Long-term Cognitive, Neuropsychiatric and Functional Outcomes in Adults Who Have Received Chimeric Antigen-Receptor T-Cell (CAR-T) Therapy for Aggressive Lymphoma at Stanford - A Pilot Study

Stanford Investigator(s)

Brian J Scott

Clinical Professor, Neurology & Neurological Sciences Clinical Associate Professor (By courtesy), Neurosurgery

Matthew Frank

Assistant Professor of Medicine (Blood and Marrow Transplantation and Cellular Therapy)

Eligibility


Inclusion Criteria:

   - >/= 18 years-old

   - Treated with Axicabtagene ciloleucel CAR-T therapy at Stanford Or

   - Treated with standard commercial Axicabtagene ciloleucel CAR-T therapy elsewhere and
   followed primarily by SHC Blood and Bone Marrow transplant providers

   - >/= 6 months from the date of CAR-T infusion

   - Fluent in English

   - Able to attend and participate in in-person testing (Arm I)

   - Able to participate in remote video testing with adequate workspace, computer and
   internet capabilities for a reliable telehealth video connection (Arm II)

Exclusion Criteria:

   - Concurrent enrollment in a CAR-T therapeutics research study

   - Unable to be present for the scheduled testing

   - Unable to participate in testing due to severe cognitive or physical limitation

   - Actively receiving chemotherapy

   - Progressive cancer

Intervention(s):

behavioral: Neuropsychological testing

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Brian J Scott, MD
bjscott@stanford.edu