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Not Recruiting
Trial ID: NCT00005777
Randomized Trial of Minimal Ventilator Support and Early Corticosteroid Therapy to Increase Survival Without Chronic Lung Disease in Extremely-Low-Birth-Weight Infants
Inclusion Criteria:
- Greater than 12 hrs of age and less than 10 days chronologic age
- 501-1000 gm
- Intubated and mechanically ventilated before 12 hrs
- Indwelling vascular catheter
- Infants 751-100 gm must be receiving FiO2 greater than 0.30 and have received at least
1 dose of surfactant at randomization
- Parental consent
Exclusion Criteria:
- Major congenital anomaly
- Symptomatic non-bacterial infection
- Permanent neuromuscular conditions that affect respiration
- Terminal illness (defined as pH values less than 6.8 for more than 2 hours or
persistent bradycardia associated with hypoxia for more than 2 hours)
- Use of postnatal corticosteroids
procedure: Minimal mechanical ventilation management
procedure: Routine mechanical ventilation management
drug: Dexamethasone
drug: Placebo
Not Recruiting
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Stanford,
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94305